Biological properties of calcium phosphate biomaterials for bone repair: a review

被引：155
作者：
Lu, Jingyi [1 ,2 ,3 ]
Yu, Huijun [1 ,2 ,3 ]
Chen, Chuanzhong [1 ,4 ]
机构：
[1] Shandong Univ, Shenzhen Res Inst, Shenzhen 518057, Guangdong, Peoples R China
[2] Shandong Univ, Key Lab High Efficiency & Clean Mech Manufacture, Minist Educ, Sch Mech Engn, Jinan 250061, Shandong, Peoples R China
[3] Shandong Univ, Natl Demonstrat Ctr Expt Mech Engn Educ, Sch Mech Engn, Jinan 250061, Shandong, Peoples R China
[4] Shandong Univ, Key Lab Liquid Solid Struct Evolut & Proc Mat, Minist Educ, Sch Mat Sci & Engn, Jinan 250061, Shandong, Peoples R China
来源：
RSC ADVANCES | 2018年 / 8卷 / 04期
关键词：
BETA-TRICALCIUM PHOSPHATE; MESENCHYMAL STEM-CELLS; SIMULATED BODY-FLUID; PARTICLE-SIZE; IN-VITRO; MECHANICAL-PROPERTIES; PHASE-COMPOSITION; OSTEOCLAST DIFFERENTIATION; HYDROXYAPATITE SCAFFOLDS; SUBSTITUTE BIOMATERIALS;
D O I：
10.1039/c7ra11278e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Bone defects are a common disease threatening the health of many people. Calcium phosphate (CaP) is an ideal bone substitutive material that is widely used for bone repair due to its excellent biological properties including osteoinductivity, osteoconductivity and biodegradability. For this reason, investigation of these properties and the effects of various influencing factors is vital for modulating calcium phosphate during the design process to maximally satisfy clinical requirements. In this study, the latest studies on the biological properties of CaP biomaterials, including hydroxyapatite (HA), tricalcium phosphate (TCP), and biphasic calcium phosphate (BCP), have been summarized. Moreover, recent advances on how these properties are altered by different factors are reviewed. Considering the limited mechanical strength of CaP materials, this study also reviews CaP composites with different materials as improvement measures. Finally, perspectives regarding future developments of CaP materials are also provided.
引用
收藏
页码：2015 / 2033
页数：19
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