Localized Fe(II)-Induced Cytotoxic Reactive Oxygen Species Generating Nanosystem for Enhanced Anticancer Therapy

被引:67
作者
Ding, Yuxue
Wan, Jiaxun
Zhang, Zihao
Wang, Fang
Guo, Jia
Wang, Changchun [1 ]
机构
[1] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
基金
美国国家科学基金会; 国家重点研发计划;
关键词
reactive oxygen species; artemisinin; magnetic nanoparticles; Fe2+-induced ROS generation; anticancer therapy; PHOTODYNAMIC THERAPY; FENTON REACTION; COLLOIDAL SUPRAPARTICLES; BIOMEDICAL APPLICATIONS; ARTEMISININ QINGHAOSU; CHINESE MEDICINE; CANCER-TREATMENT; HYPOXIC TUMOR; NANOPARTICLES; IRON;
D O I
10.1021/acsami.7b16999
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The anticancer therapy on the basis of reactive oxygen species (ROS)-mediated cellular apoptosis has achieved, great progress. However, this kind of theraputic strategy still faces some challenges such as light, photosensitizer and oxygen (O-2) dependence. In this article, a ROS-mediated anticancer therapy independent of light, photosensitizer and oxygen,was established based on a Fe2+ induced ROS-generating nanosystem. First artemisinin (ART) was loaded in porous magnetic supraparticles (MSP) by a nanodeposition method. Then, the poly(aspartic acid)-based polymer, which consisted of dopamine, indocyanine green, and polyethylene glycol' side chain, was coated onto the surface of ART-loaded MSP. When. the nanoparticles entered into cancer cells a reaction of Fe2+-inediated cleavage of the endoperoxide bridge contained in ART occurred and subsequent a large amount of ROS was generated,. Moreover, a NIR light was used to effectively increase the local temperature of tumor in virtue of the superior photothermal effects of MSP, which enabled us to accelerate the ROS generation and achieved an enhanced ROS yield. The newly developed nanochug system displayed a high level of intracellular ROS generation, leading to, the desired killing efficacy against malignant cells and solid tumor. This smart naposystern holds great potential to overcome the existing barrier in PDT and opens a promising avenue for anticancer therapy.
引用
收藏
页码:4439 / 4449
页数:11
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