Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

被引：85

作者：

Allen, Wes M. ^{[1
,2
]}

Chin, Lixin ^{[1
,2
]}

Wijesinghe, Philip ^{[1
]}

Kirk, Rodney W. ^{[1
,3
]}

Latham, Bruce ^{[4
]}

Sampson, David D. ^{[1
,5
]}

Saunders, Christobel M. ^{[6
,7
,8
]}

Kennedy, Brendan F. ^{[1
,2
]}

机构：

[1] Univ Western Australia, Sch Elect Elect & Comp Engn, Opt Biomed Engn Lab, Perth, WA 6009, Australia

[2] QEII Med Ctr, Harry Perkins Inst Med Res, BRITElab, 6 Verdun St, Nedlands, WA 6009, Australia

[3] Univ ofAdelaide, Fac Hlth Sci, Ctr Nanoscale BioPhoton, Adelaide, SA 5005, Australia

[4] Fiona Stanley Hosp, PathWest, 11 Robin Warren Dr, Murdoch, WA 6150, Australia

[5] Univ Western Australia, Ctr Microscopy Characterisat & Anal, 35 Stirling Highway, Perth, WA 6009, Australia

[6] Univ Western Australia, Sch Surg, 35 Stirling Highway, Perth, WA 6009, Australia

[7] Fiona Stanley Hosp, Breast Ctr, 11 Robin Warren Dr, Murdoch, WA 6150, Australia

[8] Royal Perth Hosp, Breast Clin, 197 Wellington St, Perth, WA 6000, Australia

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 10期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

CONSERVING SURGERY; SURGICAL MARGINS; RE-EXCISION; TOMOGRAPHY; PREDICTORS; RATES;

D O I：

10.1364/BOE.7.004139

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of similar to 50 x 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving. (C)2016 Optical Society of America

引用

页码：4139 / 4153

页数：15

共 39 条

[1]

[Anonymous], 2015, Breast Cancer Facts Figures 2015-2016

[2]

[Anonymous], OPTICAL COHERENCE TO

[3] Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience [J].

Ballal, Helen ;

Taylor, Donna B. ;

Bourke, Anita G. ;

Latham, Bruce ;

Saunders, Christobel M. .

ANZ JOURNAL OF SURGERY, 2015, 85 (7-8) :540-545

[4] Role for intraoperative margin assessment in patients undergoing breast-conserving surgery [J].

Cabioglu, Neslihan ;

Hunt, Kelly K. ;

Sahin, Aysegul A. ;

Kuerer, Henry M. ;

Babiera, Gildy V. ;

Singletary, S. Eva ;

Whitman, Gary J. ;

Ross, Merrick I. ;

Ames, Frederick C. ;

Feig, Barry W. ;

Buchholz, Thomas A. ;

Meric-Bernstam, Funda .

ANNALS OF SURGICAL ONCOLOGY, 2007, 14 (04) :1458-1471

[5] Analysis of image formation in optical coherence elastography using a multiphysics approach [J].

Chin, Lixin ;

Curatolo, Andrea ;

Kennedy, Brendan F. ;

Doyle, Barry J. ;

Munro, Peter R. T. ;

McLaughlin, Robert A. ;

Sampson, David D. .

BIOMEDICAL OPTICS EXPRESS, 2014, 5 (09) :2913-2930

[6] Intraoperative Imprint Cytology and Frozen Section Pathology for Margin Assessment in Breast Conservation Surgery: A Systematic Review [J].

Esbona, Karla ;

Li, Zhanhai ;

Wilke, Lee G. .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (10) :3236-3245

[7] THE EFFICACY OF SPECIMEN RADIOGRAPHY IN EVALUATING THE SURGICAL MARGINS OF IMPALPABLE BREAST-CARCINOMA [J].

GRAHAM, RA ;

HOMER, MJ ;

SIGLER, CJ ;

SAFAII, H ;

SCHMID, CH ;

MARCHANT, DJ ;

SMITH, TJ .

AMERICAN JOURNAL OF ROENTGENOLOGY, 1994, 162 (01) :33-36

[8] In vivo margin assessment during partial mastectomy breast surgery using Raman spectroscopy [J].

Haka, AS ;

Volynskaya, Z ;

Gardecki, JA ;

Nazemi, J ;

Lyons, J ;

Hicks, D ;

Fitzmaurice, M ;

Dasari, RR ;

Crowe, JP ;

Feld, MS .

CANCER RESEARCH, 2006, 66 (06) :3317-3322

[9] Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics [J].

Jeevan, R. ;

Cromwell, D. A. ;

Trivella, M. ;

Lawrence, G. ;

Kearins, O. ;

Pereira, J. ;

Sheppard, C. ;

Caddy, C. M. ;

van der Meulen, J. H. P. .

BMJ-BRITISH MEDICAL JOURNAL, 2012, 345

[10]

Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI [10.3322/caac.20006, 10.3322/caac.21254, 10.3322/caac.21332, 10.3322/caac.21551, 10.3322/caac.20073, 10.3322/caac.21387, 10.3322/caac.21654, 10.3322/caac.21601]

← 1 2 3 4 →