Selenenylsulfide-Linked Homogeneous Glycopeptides and Glycoproteins: Synthesis of Human "Hepatic Se Metabolite A"

被引：54

作者：

Boutureira, Omar ^{[1
]}

Bernardes, Goncalo J. L. ^{[1
]}

Fernandez-Gonzalez, Marta ^{[1
]}

Anthony, Daniel C. ^{[2
]}

Davis, Benjamin G. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 06期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

glycoproteins; metabolites; posttranslational modifications; selenium; selenoglycosides; NATIVE CHEMICAL LIGATION; AMINO-ACIDS; PROTEIN GLYCOCONJUGATION; NMR-SPECTROSCOPY; SELENIUM; SELENOCYSTEINE; SULFUR; PEPTIDES; IDENTIFICATION; BIOCHEMISTRY;

D O I：

10.1002/anie.201106658

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Introducing selenium: The synthesis and full characterization of human hepatic Se metaboliteA has been accomplished by using a robust, efficient, and Cys-specific selenenylation protocol (see scheme; NaPi=sodium phosphate). The selenenylsulfide linkage is sufficiently stable to allow quantification of Se-containing glycoconjugates in biological fluids by using atomic detection methods. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：1432 / 1436

页数：5

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