Palladium(0)-Catalyzed Intermolecular Amination of Unactivated Csp3-H Bonds

被引：135
作者：
Pan, Jun [1 ]
Su, Mingjuan [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 37期
基金：
美国国家卫生研究院;
关键词：
amines; C-H amination; homogeneous catalysis; palladium; C-H BONDS; PALLADIUM-CATALYZED AMINATION; CARBON-HYDROGEN BONDS; INTRAMOLECULAR AMIDATION; RUTHENIUM PORPHYRINS; ROOM-TEMPERATURE; NATURAL-PRODUCTS; SUZUKI-MIYAURA; FUNCTIONALIZATION; ACTIVATION;
D O I：
10.1002/anie.201102880
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Filling out the space: The title reaction of unactivated Csp 3-H bonds using aryl amines as the nitrogen source is disclosed (see scheme; dba=dibenzylideneacetone, Tf=trifluoromethanesulfonyl). Either the C-N cross-coupling product or the C-H amination product could be accessed selectively by adjusting the steric environment of the substrate. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8647 / 8651
页数：5
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