Single nucleotide polymorphisms and cancer susceptibility

被引：256
作者：
Deng, Na [1 ,2 ,3 ,4 ]
Zhou, Heng [1 ,2 ,3 ]
Fan, Hua
Yuan, Yuan [1 ,2 ,3 ,5 ]
机构：
[1] China Med Univ, Tumor Etiol & Screening Dept, Affiliated Hosp 1, Inst Canc, Shenyang 110001, Liaoning, Peoples R China
[2] China Med Univ, Gen Surg, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China
[3] China Med Univ, Key Lab Canc Etiol & Prevent, Liaoning Prov Educ Dept, Shenyang 110001, Liaoning, Peoples R China
[4] China Med Univ, Dept Hematol, Affiliated Hosp 4, Shenyang 110001, Liaoning, Peoples R China
[5] Natl Clin Res Ctr Digest Dis, Xian 110001, Shaanxi, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 66期
关键词：
single nucleotide polymorphism; genetic; epigenetic; susceptibility; cancer; LONG NONCODING RNA; CYCLIN D1 EXPRESSION; COLORECTAL-CANCER; BREAST-CANCER; FUNCTIONAL POLYMORPHISM; GENETIC-VARIANTS; SYNONYMOUS SNPS; HEPATOCELLULAR-CARCINOMA; PROMOTER POLYMORPHISMS; MOLECULAR-MECHANISM;
D O I：
10.18632/oncotarget.22372
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A large number of genes associated with various cancer types contain single nucleotide polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' - and 3' - untranslated regions (UTRs) and affect gene expression by different mechanisms. These mechanisms depend on the role of the genetic elements in which the individual SNPs are located. Moreover, alterations in epigenetic regulation due to gene polymorphisms add to the complexity underlying cancer susceptibility related to SNPs. In this systematic review, we discuss the various genetic and epigenetic mechanisms involved in determining cancer susceptibility related to various SNPs located in different genetic elements. We also discuss the diagnostic potential of these SNPs and the focus for future studies.
引用
收藏
页码：110635 / 110649
页数：15
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