DRAMing for autophagy COMMENT

被引：1

作者：

Leytens, Alexandre ^{[1
]}

Dengjel, Joern ^{[1
]}

机构：

[1] Univ Fribourg, Dept Biol, Fribourg, Switzerland

来源：

FEBS JOURNAL | 2022年 / 289卷 / 13期

关键词：

apoptosis; autophagy; DRAM; DRAM-1; DRAM-4; DRAM-5; p53; MODULATOR;

D O I：

10.1111/febs.16394

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy, a catabolic lysosomal recycling pathway, is often found dysregulated in human diseases. Whereas its prime cell stress-related function is cytoprotection, autophagy has also been linked to the activation of apoptosis and cell death. One group of proteins which participates in the orchestration of autophagy and apoptosis is the family of DRAM proteins. In the current issue of The FEBS Journal, Barthet et al. uncover a compensatory crosstalk between the two newest members of the family, DRAM-4 and DRAM-5, the latter one regulating autophagic activity.

引用

收藏

页码：3731 / 3734

页数：4

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