Protein stability: The COP9 signalosome gets in on the act

被引：26
|
作者：
Seeger, M
Gordon, C
Dubiel, W
机构：
[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[2] Humboldt Univ, Dept Surg, Div Mol Biol, Fac Med Charite, D-10117 Berlin, Germany
来源：
CURRENT BIOLOGY | 2001年 / 11卷 / 16期
关键词：
D O I：
10.1016/S0960-9822(01)00382-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The COP9 signalosome is a multiprotein complex somewhat similar to the lid component of the 26S proteasome. Recent studies suggest that it regulates the stability of proteins by interfering with the ubiquitin-proteasome pathway via deneddylation and phosphorylation.
引用
收藏
页码：R643 / R646
页数：4
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