Trichosporon asahii Infection in an Extremely Preterm Infant in China

被引：2

作者：

Wang, Na ^{[1
]}

Tang, Jing-yi ^{[2
]}

Wang, Zi ^{[3
]}

Wang, Liu-yao ^{[4
]}

Song, Tian-tian ^{[5
]}

Li, Bei-bei ^{[5
]}

Wang, Lin ^{[5
,6
]}

机构：

[1] Wuhan 1 Hosp, Dept Pediat, Wuhan, Peoples R China

[2] Wuhan 1 Hosp, Dept Pharm, Wuhan, Peoples R China

[3] Wuhan Hosp Tradit Chinese Med, Dept Dermatol, Wuhan, Peoples R China

[4] Fuyong Peoples Hosp, Dept Pediat, Shenzhen, Peoples R China

[5] Huazhong Univ Sci & Technol, Union Hosp, Dept Neonatol, Tongji Med Coll, Wuhan, Peoples R China

[6] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neonatol, Wuhan 430022, Peoples R China

来源：

INFECTION AND DRUG RESISTANCE | 2022年 / 15卷

关键词：

preterm; Trichosporon asahii; fluconazole; voriconazole; China; SEPSIS;

D O I：

10.2147/IDR.S385086

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Trichosporon asahii is an uncommon cause of fungal sepsis among neonates, but it is an important life-threatening opportunistic systemic pathogen. We report a case of T. asahii sepsis in a 980-g female baby born at 27 weeks of gestation. The extremely preterm initially presented with recurrent feeding intolerance and bloating; she subsequently developed oxygen saturation fluctuations, apnea, and a decreased heart rate. Blood culture was positive, and the causative agent was identified as T. asahii by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). According to reported minimum inhibitory concentration (MIC) values, the infant received a high dose of fluconazole (FLC, 12 mg/kg, qod) and was successfully treated.

引用

页码：6495 / 6499

页数：5

共 13 条

[1] Exploring the resistance mechanisms in Trichosporon asahii: Triazoles as the last defense for invasive trichosporonosis [J].

Barbosa Padovan, Ana Carolina ;

da Silva Rocha, Walicyranison Plinio ;

de Moraes Toti, Ana Caroline ;

Freitas de Jesus, Daniel Felipe ;

Chaves, Guilherme Maranhao ;

Colombo, Arnaldo Lopes .

FUNGAL GENETICS AND BIOLOGY, 2019, 133

[2] Multidrug-resistant Trichosporon: an unusual fungal sepsis in preterm neonates [J].

Basu, Sriparna ;

Tilak, Ragini ;

Kumar, Ashok .

PATHOGENS AND GLOBAL HEALTH, 2015, 109 (04) :202-206

[3] Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM [J].

Chen, Sharon C-A ;

Perfect, John ;

Colombo, Arnaldo L. ;

Cornely, Oliver A. ;

Groll, Andreas H. ;

Seidel, Danila ;

Albus, Kerstin ;

de Almedia, Joao Nobrega, Jr. ;

Garcia-Effron, Guillermo ;

Gilroy, Nicole ;

Lass-Floerl, Cornelia ;

Ostrosky-Zeichner, Luis ;

Pagano, Livio ;

Papp, Tamas ;

Rautemaa-Richardson, Riina ;

Salmanton-Garcia, Jon ;

Spec, Andrej ;

Steinmann, Joerg ;

Arikan-Akdagli, Sevtap ;

Arenz, Dorothee E. ;

Sprute, Rosanne ;

Duran-Graeff, Luisa ;

Freiberger, Tomas ;

Girmenia, Corrado ;

Harris, Michelle ;

Kanj, Souha S. ;

Roudbary, Maryam ;

Lortholary, Olivier ;

Meletiadis, Joseph ;

Segal, Esther ;

Tuon, Felipe Francisco ;

Wiederhold, Nathan ;

Bicanic, Tihana ;

Chander, Jagdish ;

Chen, Yee-Chun ;

Hsueh, Po-Ren ;

Ip, Margaret ;

Munoz, Patricia ;

Spriet, Isabel ;

Temfack, Elvis ;

Thompson, Luis ;

Tortorano, Anna Maria ;

Velegraki, Aristea ;

Govender, Nelesh P. .

LANCET INFECTIOUS DISEASES, 2021, 21 (12) :E375-E386

[4] Molecular evidence that the opportunistic fungal pathogen Trichosporon asahii is part of the normal fungal microbiota of the human gut based on rRNA genotyping [J].

Cho, Otomi ;

Matsukura, Manami ;

Sugita, Takashi .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2015, 39 :87-88

[5] Current Knowledge of Trichosporon spp. and Trichosporonosis [J].

Colombo, Arnaldo L. ;

Padovan, Ana Carolina B. ;

Chaves, Guilherme M. .

CLINICAL MICROBIOLOGY REVIEWS, 2011, 24 (04) :682-+

[6] Trichosporonosis in Pediatric Patients With a Hematologic Disorder [J].

Foster, Catherine E. ;

Edwards, Morven S. ;

Brackett, Julienne ;

Schady, Deborah A. ;

Healy, C. Mary ;

Baker, Carol J. .

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2018, 7 (03) :199-204

[7] Species distribution and antifungal susceptibility of 358 Trichosporon clinical isolates collected in 24 medical centres [J].

Francisco, E. C. ;

de Almeida Junior, J. N. ;

de Queiroz Telles, F. ;

Aquino, V. R. ;

Mendes, A. V. A. ;

de Andrade Barberino, M. G. M. ;

Castro, P. de Tarso O. ;

Guimaraes, T. ;

Hahn, R. C. ;

Padovan, A. C. B. ;

Chaves, G. M. ;

Colombo, A. L. .

CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (07) :909.e1-909.e5

[8] Invasive Infections Due to Trichosporon: Species Distribution, Genotyping, and Antifungal Susceptibilities from a Multicenter Study in China [J].

Guo, Li-Na ;

Yu, Shu-Ying ;

Hsueh, Po-Ren ;

Al-Hatmi, Abdullah M. S. ;

Meis, Jacques F. ;

Hagen, Ferry ;

Xiao, Meng ;

Wang, He ;

Barresi, Cinzia ;

Zhou, Meng-Lan ;

de Hoog, G. Sybren ;

Xu, Ying-Chun .

JOURNAL OF CLINICAL MICROBIOLOGY, 2019, 57 (02)

[9] Epidemiology and Outcome of Trichosporon Fungemia: A Review of 185 Reported Cases From 1975 to 2014 [J].

Liao, Yong ;

Lu, Xuelian ;

Yang, Suteng ;

Luo, Yi ;

Chen, Qi ;

Yang, Rongya .

OPEN FORUM INFECTIOUS DISEASES, 2015, 2 (04)

[10]

Pappas PG, 2016, CLIN INFECT DIS, V62, P409, DOI 10.1093/cid/civ1194

← 1 2 →