Risk of infant anemia is associated with exclusive breast-feeding and maternal anemia in a Mexican cohort.

被引:91
作者
Meinzen-Derr, JK
Guerrero, ML
Altaye, M
Otega-Gallegos, H
Ruiz-Palacios, GM
Morrow, AL [1 ]
机构
[1] Univ Cincinnati, Coll Med, Ctr Biostat & Epidemiol, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45221 USA
[2] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA
[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Infectol, Mexico City, DF, Mexico
关键词
infant anemia; maternal anemia; exclusive breast-feeding;
D O I
10.1093/jn/136.2.452
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The WHO recommends exclusive breast-feeding (EBIF) for the first 6 mo of life to decrease the burden of infectious disease. However, some are concerned about the effect of EBIF > 6 mo on iron status of children in developing countries in which anemia is prevalent. This study examines the risk of anemia in relation to the duration of EBIF and maternal anemia in a birth cohort studied between March 1998 and April 2003. All infant birth weights were >= 2.2 kg. All mothers received home-based peer counseling to promote EBF. Infant feeding data were collected weekly. Nurses measured hemoglobin (Hb) values every 3 mo. Hb was measured in 183 infants at 9 mo of age. Anemia at 9 mo was defined as a Hb value < 100 g/L. EBF was defined by WHO criteria and ranged in duration from 0 to 31 wk. At 9 mo, Hb (mean +/- SEM) was 114 +/- 0.9 g/L; 23 children (12.5%) had Hb levels < 100 g/L. EBF > 6 mo, but not EBIF 4-6 mo, was associated with increased risk of infant anemia compared with EBF < 4 mo (odds ratio = 18.4, 95% Cl = 1.9, 174.0). Maternal anemia was independently (P = 0.03) associated with a 3-fold increased risk of infant anemia. These associations were not explained by confounding with other maternal or infant factors. By linear regression, a lower infant Hb at 9 mo was associated with increased EBF duration among mothers who had a history of anemia (beta = -0.07, P = 0.003), but not among mothers with no history of anemia. Infants who are exclusively breast-fed for > 6 mo in developing countries may be at increased risk of anemia, especially among mothers with a poor iron status; greater attention to this issue is warranted.
引用
收藏
页码:452 / 458
页数:7
相关论文
共 58 条
  • [1] Evaluation of kits for measurement of the soluble transferrin receptor
    Åkesson, A
    Bjellerup, P
    Vahter, M
    [J]. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1999, 59 (02) : 77 - 81
  • [2] Serum transferrin receptor:: a specific marker of iron deficiency in pregnancy
    Åkesson, A
    Bjellerup, P
    Berglund, M
    Bremme, K
    Vahter, M
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 68 (06) : 1241 - 1246
  • [3] [Anonymous], 1998, MMWR Recomm Rep, V47, P1
  • [4] [Anonymous], 1992, INT C NUTR WORLD DEC
  • [5] [Anonymous], 2001, Global strategy for infant and young child feeding
  • [6] BINKIN NJ, 1990, COLLOQ INSE, V197, P137
  • [7] BRIDGES N, 1987, AM CLIN PROD REV, V22, P2
  • [8] CALVO EB, 1992, PEDIATRICS, V90, P375
  • [9] CARLSON DA, 1987, 40 ANN M AM ASS BLOO
  • [10] CELADA A, 1982, HELV PAEDIATR ACTA, V37, P11