Pathophysiology of fluid administration in critically ill patients

被引:26
作者
Messina, Antonio [1 ,2 ]
Bakker, Jan [3 ,4 ,5 ]
Chew, Michelle [6 ]
De Backer, Daniel [7 ]
Hamzaoui, Olfa [8 ]
Hernandez, Glenn [9 ]
Myatra, Sheila Nainan [10 ]
Monnet, Xavier [11 ]
Ostermann, Marlies [12 ]
Pinsky, Michael [13 ]
Teboul, Jean-Louis [11 ]
Cecconi, Maurizio [1 ,2 ]
机构
[1] IRCCS Humanitas Res Hosp, Via Alessandro Manzoni 56, I-20089 Milan, Italy
[2] Humanitas Univ, Dept Biomed Sci, Milan, Italy
[3] NYU Langone Hlth, New York, NY USA
[4] Columbia Univ, Irving Med Ctr, New York, NY USA
[5] Erasmus MC Univ Med Ctr, Rotterdam, Netherlands
[6] Linkoping Univ, Dept Anaesthesia & Intens Care, Biomed & Clin Sci, Linkoping, Sweden
[7] Univ Libre Bruxelles, CHIREC Hosp, Dept Intens Care, Brussels, Belgium
[8] Hop Univ Paris Saclay, Serv Reanimat, PolyvalenteHop Antoine Beclere, Clamart, France
[9] Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile
[10] Tata Mem Hosp, Homi Bhabha Natl Inst, Dept Anaesthesiol Crit Care & Pain, Mumbai, Maharashtra, India
[11] Hop Bicetre, Med Intens Care Unit, Hop Univ Paris Sud, Paris, France
[12] Kings Coll London, Dept Intens Care, Guys & St Thomas Hosp, London, England
[13] Univ Pittsburgh, Dept Crit Care Med, Pittsburgh, PA USA
关键词
SURVIVING SEPSIS CAMPAIGN; INTENSIVE-CARE-UNIT; GOAL-DIRECTED RESUSCITATION; ACUTE KIDNEY INJURY; SEPTIC SHOCK; INTERNATIONAL GUIDELINES; PERIPHERAL PERFUSION; HYDROXYETHYL STARCH; ARTERIAL-PRESSURE; LACTATE CLEARANCE;
D O I
10.1186/s40635-022-00473-4
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Fluid administration is a cornerstone of treatment of critically ill patients. The aim of this review is to reappraise the pathophysiology of fluid therapy, considering the mechanisms related to the interplay of flow and pressure variables, the systemic response to the shock syndrome, the effects of different types of fluids administered and the concept of preload dependency responsiveness. In this context, the relationship between preload, stroke volume (SV) and fluid administration is that the volume infused has to be large enough to increase the driving pressure for venous return, and that the resulting increase in end-diastolic volume produces an increase in SV only if both ventricles are operating on the steep part of the curve. As a consequence, fluids should be given as drugs and, accordingly, the dose and the rate of administration impact on the final outcome. Titrating fluid therapy in terms of overall volume infused but also considering the type of fluid used is a key component of fluid resuscitation. A single, reliable, and feasible physiological or biochemical parameter to define the balance between the changes in SV and oxygen delivery (i.e., coupling "macro" and "micro" circulation) is still not available, making the diagnosis of acute circulatory dysfunction primarily clinical.
引用
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页数:15
相关论文
共 105 条
[1]   Capillary refill time exploration during septic shock [J].
Ait-Oufella, H. ;
Bige, N. ;
Boelle, P. Y. ;
Pichereau, C. ;
Alves, M. ;
Bertinchamp, R. ;
Baudel, J. L. ;
Galbois, A. ;
Maury, E. ;
Guidet, B. .
INTENSIVE CARE MEDICINE, 2014, 40 (07) :958-964
[2]   Mottling score predicts survival in septic shock [J].
Ait-Oufella, H. ;
Lemoinne, S. ;
Boelle, P. Y. ;
Galbois, A. ;
Baudel, J. L. ;
Lemant, J. ;
Joffre, J. ;
Margetis, D. ;
Guidet, B. ;
Maury, E. ;
Offenstadt, G. .
INTENSIVE CARE MEDICINE, 2011, 37 (05) :801-807
[3]   Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock The CRISTAL Randomized Trial [J].
Annane, Djillali ;
Siami, Shidasp ;
Jaber, Samir ;
Martin, Claude ;
Elatrous, Souheil ;
Declere, Adrien Descorps ;
Preiser, Jean Charles ;
Outin, Herve ;
Troche, Gilles ;
Charpentier, Claire ;
Trouillet, Jean Louis ;
Kimmoun, Antoine ;
Forceville, Xavier ;
Darmon, Michael ;
Lesur, Olivier ;
Regnier, Jean ;
Abroug, Fekri ;
Berger, Philippe ;
Clec'h, Christophe ;
Cousson, Joel ;
Thibault, Laure ;
Chevret, Sylvie .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 310 (17) :1809-1817
[4]   Hemodynamic Effect of Different Doses of Fluids for a Fluid Challenge: A Quasi-Randomized Controlled Study [J].
Aya, Hollmann D. ;
Rhodes, Andrew ;
Ster, Irina Chis ;
Fletcher, Nick ;
Grounds, R. Michael ;
Cecconi, Maurizio .
CRITICAL CARE MEDICINE, 2017, 45 (02) :E161-E168
[5]   Pharmacodynamic Analysis of a Fluid Challenge [J].
Aya, Hollmann D. ;
Ster, Irina Chis ;
Fletcher, Nick ;
Grounds, Michael ;
Rhodes, Andrew ;
Cecconi, Maurizio .
CRITICAL CARE MEDICINE, 2016, 44 (05) :880-891
[6]   MALIC ENZYME LEVELS ARE INCREASED BY THE ACTIVATION OF NADPH-CONSUMING PATHWAYS - DETOXIFICATION PROCESSES [J].
AYALA, A ;
FLOBATO, M ;
MACHADO, A .
FEBS LETTERS, 1986, 202 (01) :102-106
[7]   Current practice and evolving concepts in septic shock resuscitation [J].
Bakker, Jan ;
Kattan, Eduardo ;
Annane, Djillali ;
Castro, Ricardo ;
Cecconi, Maurizio ;
de Backer, Daniel ;
Dubin, Arnaldo ;
Evans, Laura ;
Gong, Michelle Ng ;
Hamzaoui, Olfa ;
Ince, Can ;
Levy, Bruno ;
Monnet, Xavier ;
Ospina Tascon, Gustavo A. ;
Ostermann, Marlies ;
Pinsky, Michal R. ;
Russell, James A. ;
Saugel, Bernd ;
Scheeren, Thomas W. L. ;
Teboul, Jean-Louis ;
Baron, Antoine Vieillard ;
Vincent, Jean-Louis ;
Zampieri, Fernando G. ;
Hernandez, Glenn .
INTENSIVE CARE MEDICINE, 2022, 48 (02) :148-163
[8]   Machine learning methods to improve bedside fluid responsiveness prediction in severe sepsis or septic shock: an observational study [J].
Bataille, Benoit ;
de Selle, Jade ;
Moussot, Pierre-Etienne ;
Marty, Philippe ;
Silva, Stein ;
Cocquet, Pierre .
BRITISH JOURNAL OF ANAESTHESIA, 2021, 126 (04) :826-834
[9]   Venous oximetry [J].
Bloos, F ;
Reinhart, K .
INTENSIVE CARE MEDICINE, 2005, 31 (07) :911-913
[10]   Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality [J].
Boyd, John H. ;
Forbes, Jason ;
Nakada, Taka-aki ;
Walley, Keith R. ;
Russell, James A. .
CRITICAL CARE MEDICINE, 2011, 39 (02) :259-265