Clinical insights by the presence of bipolar disorder in pseudohypoparathyroidism type 1A

被引：6

作者：

Kadilli, Irket ^{[1
]}

Colicchio, Salvatore ^{[1
]}

Guglielmo, Riccardo ^{[1
]}

Vollono, Catello ^{[2
]}

della Marca, Giacomo ^{[2
]}

Janiri, Luigi ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Psychiat & Psychol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Inst Neurol, I-00168 Rome, Italy

来源：

GENERAL HOSPITAL PSYCHIATRY | 2015年 / 37卷 / 05期

关键词：

Bipolar disorder; Pseudohypoparathyroidism type 1A; GNAS1; mutation; Vitamin D deficiency; PARATHYROID-HORMONE; VITAMIN-D; CALCIUM;

D O I：

10.1016/j.genhosppsych.2015.06.008

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Pseudohypoparathyroidism type 1A and its association with bipolar disorder (BD) have never been reported so far. We report a new case with both clinical entities and discuss the potential pathophysiological mechanisms of this association (protein kinase A hypoactivation, parathyroid hormone, hypocalcemia, protein kinase C activation, vitamin D deficiency). In this patient, the correction of the underlying calcium and vitamin D deficiencies leads to a better BD outcome and lower dosage of psychopharmacological agents. The conclusions might be generalized for a better understanding and management of these conditions. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：497.e3 / 497.e5

页数：3

共 14 条

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