Effects of Daintain/AIF-1 on β Cell Dysfunction in INS-1 Cells

被引：8
作者：
Huang, Xinyuan [1 ]
Zhao, Yanying [2 ]
Jia, Shaohui [1 ]
Yan, Dongjing [1 ]
Chen, Zhengwang [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Key Lab Mol Biophys, Minist Educ, Coll Life Sci & Technol, Wuhan 430074, Hubei, Peoples R China
[2] SW Univ Nationnalities, Sch Life Sci & Technol, Chengdu 610041, Sichuan, Peoples R China
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2011年 / 75卷 / 09期
基金：
美国国家科学基金会;
关键词：
daintain/AIF-1; INS-1; cell; beta cell dysfunction; type-1; diabetes; cytotoxicity; INFLAMMATORY FACTOR-I; DEPENDENT DIABETES-MELLITUS; NITRIC-OXIDE; EXPRESSION; FACTOR-1; DESTRUCTION; NEURITIS; CLONING; GROWTH; VITRO;
D O I：
10.1271/bbb.110317
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effects of daintain/AIF-1, a novel inflammatory cytokine, on INS-1 beta cells. Cells incubated with daintain/AIF-1 showed decreased cell viability and glucose-stimulated insulin secretion, as well as upregulated apoptosis and NO production. These deleterious effects of daintain/AIF-1 indicate that daintain/AIF-1 plays important roles in the dysfunction of pancreatic beta cells in type-1 diabetes.
引用
收藏
页码：1842 / 1844
页数：3
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