Meningococcal genome dynamics

被引：73
作者：
Davidsen, T
Tonjum, T [1 ]
机构：
[1] Univ Oslo, Ctr Mol Biol & Neurosci, Rikshosp, N-0027 Oslo, Norway
[2] Univ Oslo, Inst Microbiol, Rikshosp, N-0027 Oslo, Norway
来源：
NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 01期
关键词：
D O I：
10.1038/nrmicro1324
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Neisseria meningitidis (the meningococcus) is an important commensal, pathogen and model organism that faces up to the environment in its exclusive human host with a small but hyperdynamic genome. Compared with Escherichia coli, several DNA-repair genes are absent in N. meningitidis, whereas the gene products of others interact differently. Instead of responding to external stimuli, the meningococcus spontaneously produces a plethora of genetic variants. The frequent genomic alterations and polymorphisms have profound consequences for the interaction of this microorganism with its host, impacting structural and antigenic changes in crucial surface components that are relevant for adherence and invasion as well as antibiotic resistance and vaccine development.
引用
收藏
页码：11 / 22
页数：12
相关论文
共 132 条
  • [41] Costs and benefits of high mutation rates: Adaptive evolution of bacteria in the mouse gut
    Giraud, A
    Matic, I
    Tenaillon, O
    Clara, A
    Radman, M
    Fons, M
    Taddei, F
    [J]. SCIENCE, 2001, 291 (5513) : 2606 - 2608
  • [42] IDENTIFICATION AND ARRANGEMENT OF THE DNA-SEQUENCE RECOGNIZED IN SPECIFIC TRANSFORMATION OF NEISSERIA-GONORRHOEAE
    GOODMAN, SD
    SCOCCA, JJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) : 6982 - 6986
  • [43] GRAVES JF, 1982, J BACTERIOL, V152, P1071
  • [44] INTRAGENIC RECOMBINATION LEADS TO PILUS ANTIGENIC VARIATION IN NEISSERIA-GONORRHOEAE
    HAGBLOM, P
    SEGAL, E
    BILLYARD, E
    SO, M
    [J]. NATURE, 1985, 315 (6015) : 156 - 158
  • [45] Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): Correlation with bacterial invasion and the outbreak of meningococcal disease
    Hammerschmidt, S
    Muller, A
    Sillmann, H
    Muhlenhoff, M
    Borrow, R
    Fox, A
    vanPutten, J
    Zollinger, WD
    GerardySchahn, R
    Frosch, M
    [J]. MOLECULAR MICROBIOLOGY, 1996, 20 (06) : 1211 - 1220
  • [46] Subpathways of nucleotide excision repair and their regulation
    Hanawalt, PC
    [J]. ONCOGENE, 2002, 21 (58) : 8949 - 8956
  • [47] Interactions of Neisseria meningitidis with cells of the human meninges
    Hardy, SJ
    Christodoulides, M
    Weller, RO
    Heckels, JE
    [J]. MOLECULAR MICROBIOLOGY, 2000, 36 (04) : 817 - 829
  • [48] ISOLATION AND CHARACTERIZATION OF MUTANTS WITH LESIONS AFFECTING PELLICLE FORMATION AND ERYTHROCYTE AGGLUTINATION BY TYPE-1 PILIATED ESCHERICHIA-COLI
    HARRIS, SL
    ELLIOTT, DA
    BLAKE, MC
    MUST, LM
    MESSENGER, M
    ORNDORFF, PE
    [J]. JOURNAL OF BACTERIOLOGY, 1990, 172 (11) : 6411 - 6418
  • [49] AN UNMODIFIED HEPTADECAPEPTIDE PHEROMONE INDUCES COMPETENCE FOR GENETIC-TRANSFORMATION IN STREPTOCOCCUS-PNEUMONIAE
    HAVARSTEIN, LS
    COOMARASWAMY, G
    MORRISON, DA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) : 11140 - 11144
  • [50] Molecular switches - the ON and OFF of bacterial phase variation
    Henderson, IR
    Owen, P
    Nataro, JP
    [J]. MOLECULAR MICROBIOLOGY, 1999, 33 (05) : 919 - 932
12345678910