Meningococcal genome dynamics

被引：73
作者：
Davidsen, T
Tonjum, T [1 ]
机构：
[1] Univ Oslo, Ctr Mol Biol & Neurosci, Rikshosp, N-0027 Oslo, Norway
[2] Univ Oslo, Inst Microbiol, Rikshosp, N-0027 Oslo, Norway
来源：
NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 01期
关键词：
D O I：
10.1038/nrmicro1324
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Neisseria meningitidis (the meningococcus) is an important commensal, pathogen and model organism that faces up to the environment in its exclusive human host with a small but hyperdynamic genome. Compared with Escherichia coli, several DNA-repair genes are absent in N. meningitidis, whereas the gene products of others interact differently. Instead of responding to external stimuli, the meningococcus spontaneously produces a plethora of genetic variants. The frequent genomic alterations and polymorphisms have profound consequences for the interaction of this microorganism with its host, impacting structural and antigenic changes in crucial surface components that are relevant for adherence and invasion as well as antibiotic resistance and vaccine development.
引用
收藏
页码：11 / 22
页数：12
相关论文
共 132 条
  • [1] An inhibitor of DNA binding and uptake events dictates the proficiency of genetic transformation in Neisseria gonorrhoeae:: mechanism of action and links to Type IV pilus expression
    Aas, FE
    Lovold, C
    Koomey, M
    [J]. MOLECULAR MICROBIOLOGY, 2002, 46 (05) : 1441 - 1450
  • [2] CHARACTERIZATION OF THE OPA (CLASS-5) GENE FAMILY OF NEISSERIA-MENINGITIDIS
    AHO, EL
    DEMPSEY, JA
    HOBBS, MM
    KLAPPER, DG
    CANNON, JG
    [J]. MOLECULAR MICROBIOLOGY, 1991, 5 (06) : 1429 - 1437
  • [3] Identification of Neisseria meningitidis genetic loci involved in the modulation of phase variation frequencies
    Alexander, HL
    Rasmussen, AW
    Stojiljkovic, I
    [J]. INFECTION AND IMMUNITY, 2004, 72 (11) : 6743 - 6747
  • [4] Natural transformation and phase variation modulation in Neisseria meningitidis
    Alexander, HL
    Richardson, AR
    Stojiljkovic, I
    [J]. MOLECULAR MICROBIOLOGY, 2004, 52 (03) : 771 - 783
  • [5] Transformation of MutL by ATP binding and hydrolysis: A switch in DNA mismatch repair
    Ban, C
    Junop, M
    Yang, W
    [J]. CELL, 1999, 97 (01) : 85 - 97
  • [6] H-DNA FORMATION BY THE CODING REPEAT ELEMENTS OF NEISSERIAL OPA GENES
    BELLAND, RJ
    [J]. MOLECULAR MICROBIOLOGY, 1991, 5 (10) : 2351 - 2360
  • [7] Berrington AW, 2002, FEMS IMMUNOL MED MIC, V34, P267, DOI 10.1111/j.1574-695X.2002.tb00633.x
  • [8] THE OPACITY PROTEINS OF NEISSERIA-GONORRHOEAE STRAIN MS11 ARE ENCODED BY A FAMILY OF 11 COMPLETE GENES
    BHAT, KS
    GIBBS, CP
    BARRERA, O
    MORRISON, SG
    JAHNIG, F
    STERN, A
    KUPSCH, EM
    MEYER, TF
    SWANSON, J
    [J]. MOLECULAR MICROBIOLOGY, 1991, 5 (08) : 1889 - 1901
  • [9] FACTORS AFFECTING GENETIC TRANSFORMATION OF NEISSERIA-GONORRHOEAE
    BISWAS, GD
    SOX, T
    BLACKMAN, E
    SPARLING, PF
    [J]. JOURNAL OF BACTERIOLOGY, 1977, 129 (02) : 983 - 992
  • [10] Disruption of the helix-u-turn-helix motif of MutS protein: Loss of subunit dimerization, mismatch binding and ATP hydrolysis
    Biswas, I
    Obmolova, G
    Takahashi, M
    Herr, A
    Newman, MA
    Yang, W
    Hsieh, P
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2001, 305 (04) : 805 - 816
12345678910