Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

被引：107
|
作者：
Cheng, Yu [3 ]
Meyers, Joseph D. [1 ,2 ]
Agnes, Richard S. [1 ,2 ]
Doane, Tennyson L. [3 ]
Kenney, Malcolm E. [3 ]
Broome, Ann-Marie [1 ,2 ]
Burda, Clemens [3 ]
Basilion, James P. [1 ,2 ]
机构：
[1] Case Western Reserve Univ, Ctr Mol Imaging, NFCR Ctr Mol Imaging Case, Dept Biomed Engn, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA
来源：
SMALL | 2011年 / 7卷 / 16期
关键词：
PHOTODYNAMIC THERAPY; COLLOIDAL GOLD; CANCER; GROWTH; PHOTOSENSITIZER; THERAPEUTICS; MECHANISM; VECTORS; RELEASE; GLIOMA;
D O I：
10.1002/smll.201100628
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2301 / 2306
页数：6
相关论文
共 50 条
  • [41] Synthesis and Evaluation of Doxorubicin-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery
    Du, Yongle
    Xia, Long
    Jo, Ami
    Davis, Richey M.
    Bissel, Philippe
    Ehrich, Marion F.
    Kingston, David G. I.
    BIOCONJUGATE CHEMISTRY, 2018, 29 (02) : 420 - 430
  • [42] Synthesis and characterization of Arabic gum capped gold nanoparticles for tumor-targeted drug delivery
    Devi, P. Renuga
    Kumar, C. Senthil
    Selvamani, P.
    Subramanian, N.
    Ruckmani, K.
    MATERIALS LETTERS, 2015, 139 : 241 - 244
  • [43] How to Develop Drug Delivery System Based on Carbohydrate Nanoparticles Targeted to Brain Tumors
    Silant'ev, Vladimir E.
    Shmelev, Mikhail E.
    Belousov, Andrei S.
    Patlay, Aleksandra A.
    Shatilov, Roman A.
    Farniev, Vladislav M.
    Kumeiko, Vadim V.
    POLYMERS, 2023, 15 (11)
  • [44] Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery
    Paciotti, Giulio F.
    Zhao, Jielu
    Cao, Shugeng
    Brodie, Peggy J.
    Tamarkin, Lawrence
    Huhta, Marja
    Myer, Lonnie D.
    Friedman, Jay
    Kingston, David G. I.
    BIOCONJUGATE CHEMISTRY, 2016, 27 (11) : 2646 - 2657
  • [45] Gold nanoparticles and their applications in transdermal drug delivery: A review
    Singpanna, Kanokwan
    Pornpitchanarong, Chaiyakarn
    Patrojanasophon, Prasopchai
    Rojanarata, Theerasak
    Ngawhirunpat, Tanasait
    Li, S. Kevin
    Opanasopit, Praneet
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2023, 90
  • [46] Using Gold Nanoparticles as Delivery Vehicles for Targeted Delivery of Chemotherapy Drug Fludarabine Phosphate to Treat Hematological Cancers
    Song, Steven
    Hao, Yuzhi
    Yang, Xiaoyan
    Patra, Prabir
    Chen, Jie
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 16 (03) : 2582 - 2586
  • [47] Multi-functional gold nanoparticles for drug delivery
    Han, Gang
    Ghosh, Partha
    Rotello, Vincent M.
    BIO-APPLICATIONS OF NANOPARTICLES, 2007, 620 : 48 - 56
  • [48] Gold/Chitosan/Pluronic nanoparticles for drug delivery composite
    Oh, Keun Sang
    Kim, Ree Sun
    Lee, Jinho
    Kim, Dongmin
    Cho, Sun Hang
    Yuk, Soon Hong
    JOURNAL OF APPLIED POLYMER SCIENCE, 2008, 108 (05) : 3239 - 3244
  • [49] Gold Nanoparticles in Drug Delivery Systems: Therapeutic Applications
    Devi, Meena
    Awasthi, Shachi
    ADVANCES IN BASIC SCIENCES (ICABS 2019), 2019, 2142
  • [50] Multifunctional DNA-Gold Nanoparticles for Targeted Doxorubicin Delivery
    Alexander, Colleen M.
    Hamner, Kristen L.
    Maye, Mathew M.
    Dabrowiak, James C.
    BIOCONJUGATE CHEMISTRY, 2014, 25 (07) : 1261 - 1271
12345