Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

被引：107

作者：

Cheng, Yu ^{[3
]}

Meyers, Joseph D. ^{[1
,2
]}

Agnes, Richard S. ^{[1
,2
]}

Doane, Tennyson L. ^{[3
]}

Kenney, Malcolm E. ^{[3
]}

Broome, Ann-Marie ^{[1
,2
]}

Burda, Clemens ^{[3
]}

Basilion, James P. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Ctr Mol Imaging, NFCR Ctr Mol Imaging Case, Dept Biomed Engn, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA

来源：

SMALL | 2011年 / 7卷 / 16期

关键词：

PHOTODYNAMIC THERAPY; COLLOIDAL GOLD; CANCER; GROWTH; PHOTOSENSITIZER; THERAPEUTICS; MECHANISM; VECTORS; RELEASE; GLIOMA;

D O I：

10.1002/smll.201100628

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2301 / 2306

页数：6