Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

被引：107
|
作者：
Cheng, Yu [3 ]
Meyers, Joseph D. [1 ,2 ]
Agnes, Richard S. [1 ,2 ]
Doane, Tennyson L. [3 ]
Kenney, Malcolm E. [3 ]
Broome, Ann-Marie [1 ,2 ]
Burda, Clemens [3 ]
Basilion, James P. [1 ,2 ]
机构：
[1] Case Western Reserve Univ, Ctr Mol Imaging, NFCR Ctr Mol Imaging Case, Dept Biomed Engn, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA
来源：
SMALL | 2011年 / 7卷 / 16期
关键词：
PHOTODYNAMIC THERAPY; COLLOIDAL GOLD; CANCER; GROWTH; PHOTOSENSITIZER; THERAPEUTICS; MECHANISM; VECTORS; RELEASE; GLIOMA;
D O I：
10.1002/smll.201100628
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2301 / 2306
页数：6
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