Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin

被引：27

作者：

Danciu, Corina ^{[1
]}

Oprean, Camelia ^{[2
]}

Coricovac, Dorina E. ^{[3
]}

Andreea, Cioca ^{[4
]}

Cimpean, Anca ^{[5
]}

Radeke, Heinfried ^{[6
]}

Soica, Codruta ^{[2
]}

Dehelean, Cristina ^{[3
]}

机构：

[1] Univ Med & Farm Timisoara, Dept Pharmacognosy, Timisoara 300041, Romania

[2] Univ Med & Farm Timisoara, Dept Pharmaceut Chem, Timisoara 300041, Romania

[3] Univ Med & Farm Timisoara, Dept Toxicol, Timisoara 300041, Romania

[4] Iuliu Hatieganu Univ Med & Pharm, Dept Pathol, Cluj Napoca, Romania

[5] Univ Med & Farm Timisoara, Dept Microscop Morphol Histol, Angiogenesis Res Ctr, Timisoara 300041, Romania

[6] Clin JW Goethe Univ, Pharmazentrum Frankfurt, Ctr Drug Res Dev & Safety, D-60054 Frankfurt, Germany

来源：

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY | 2015年 / 96卷 / 02期

关键词：

B164A5; B16F10; B16FLT3; B16GMCSF; C57BL/6J; ENDOTHELIAL GROWTH-FACTOR; COLONY-STIMULATING FACTOR; GM-CSF; MALIGNANT-MELANOMA; BRENNER SIGN; MICE; MELANOGENESIS; METASTASIS; IMMUNOTHERAPY; IMMUNIZATION;

D O I：

10.1111/iep.12114

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. The aim of this study was to explore the behaviour of four different B16 murine melanoma cell sublines after inoculation into C57BL/6J mice; and, more specifically to analyse skin changes, with respect to two specific parameters: clinical (tumour volume, melanin amount, erythema) and histological (H & E, S100, VEGF expression). Both non-invasive and invasive analysis showed that B164A5 is the most aggressive melanoma cell line for C57BL/ 6J's skin, followed by B16F10 and then by diminished aggressive growth pattern by the B16GMCSF and B16FLT3 cell lines.

引用

页码：73 / 80

页数：8

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