The culture of olfactory ensheathing cells (OECs)-a distinct glial cell type

被引：53

作者：

Higginson, Jennifer R. ^{[1
]}

Barnett, Susan C. ^{[1
]}

机构：

[1] Univ Glasgow, Glasgow Biomed Res Ctr, Coll Med Vet & Life Sci MVLS, Inst Infect Immun & Inflammat, Glasgow G12 8TA, Lanark, Scotland

来源：

EXPERIMENTAL NEUROLOGY | 2011年 / 229卷 / 01期

基金：

英国惠康基金;

关键词：

Olfactory ensheathing cells; Culture; Purification; Maintenance; Molecular and cellular; Properties; CANINE SCHWANN-CELLS; SPINAL-CORD-INJURY; NERVE-FIBER LAYER; IN-VITRO; NEURITE OUTGROWTH; MENINGEAL CELLS; GROWTH-FACTORS; AXONAL GROWTH; N-CAM; ADULT;

D O I：

10.1016/j.expneurol.2010.08.020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Olfactory ensheathing cells (OECs) have become a popular candidate for the transplant-mediated repair of the damaged CNS. In this review a description is made of the origins of these cells and a historical development of their purification and maintenance in culture. In addition, we illustrate the cellular and molecular characteristics of OECs and emphasise that although they share many properties with Schwann cells, they possess several inherent differences which may allow them to be more beneficial for CNS repair. In summary, OECs are distinct glial cells and the detailed understanding of their biological and molecular properties is essential in ensuring their clinical efficacy after cell transplantation. This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：2 / 9

页数：8

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