Reference values for young normal Sprague-Dawley rats: Weight gain, hematology and clinical chemistry

被引：87

作者：

Lillie, LE ^{[1
]}

Temple, NJ ^{[1
]}

Florence, LZ ^{[1
]}

机构：

[1] ALBERTA ENVIRONM CTR,VEGREVILLE,AB T9C 1T4,CANADA

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1996年 / 15卷 / 08期

关键词：

blood chemical analysis; body temperature; electrolytes; body weight;

D O I：

10.1177/096032719601500802

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 Arterial blood from 63 male (315-500 g) and 60 female (210-290 g) healthy Sprague-Dawley rats was analyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38-78 days and females 49-89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperimental variation was as much as +/- 22%. 4 Rectal temperatures of females averaged 37.28 degrees C, being statistically greater (P<0.05) than the average male at 36.99 degrees C. 5 The data provide reference values for use in toxicological and other investigations.

引用

页码：612 / 616

页数：5

共 16 条

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