Antibacterial activities of zeolite/silver-graphene oxide nanocomposite in bone implants

被引：23

作者：

Abed, Solmaz ^{[1
]}

Bakhsheshi-Rad, Hamid Reza ^{[2
]}

Yaghoubi, Hashem ^{[1
]}

Ning, Liqun ^{[3
]}

Sadeghianmaryan, Ali ^{[4
,5
]}

Chen, Xiongbiao ^{[3
,5
]}

机构：

[1] Islamic Azad Univ, Dept Biol, Ardabil Branch, Ardebil 5615731567, Iran

[2] Islamic Azad Univ, Adv Mat Res Ctr, Dept Mat Engn, Najafabad Branch, Najafabad, Iran

[3] Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK, Canada

[4] Islamic Azad Univ, Dept Chem, Ardabil Branch, Ardebil, Iran

[5] Univ Saskatchewan, Coll Engn, Div Biomed Engn, Saskatoon, SK, Canada

来源：

MATERIALS TECHNOLOGY | 2021年 / 36卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Zeolite; graphene oxide; antibacterial activity; biocompatibility; DRUG-RELEASE; HYDROXYAPATITE; OSTEOBLASTS; BIOACTIVITY; GROWTH;

D O I：

10.1080/10667857.2020.1786784

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The capability to hinder microbial growth on the implant surfaces is of great interest in medical applications. This paper presents our study on the synthesis of zeolite/silver-graphene oxide (Zeo/Ag-GO) nanocomposite to enhance antibacterial activities of bone implants. Zeo/Ag-GO was synthesized using via semi-powder metallurgy and then characterized in terms of microstructure, antibacterial activities, and biocompatibility. Our microstructure results demonstrated that the Ag particles were anchored and uniformly distributed in the composite structure; assessment of antibacterial activity against the Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) revealed that Zeo/Ag-GO was better than Zeo/Ag, but Zeo has no antimicrobial activity observed; and biocompatibility assays showed that both Zeo/Ag and Zeo/Ag-GO had no negative effect on the proliferation of MG-63, while Zeo/Ag-GO promoted better cell viability. Taken together, Zeo/Ag-GO has great antimicrobial performance with suitable cytocompatibility, thus potentially being used to reduce implant-associated infections.

引用

页码：660 / 669

页数：10

共 30 条

[1] A new multifunctional monticellite-ciprofloxacin scaffold: Preparation, bioactivity, biocompatibility, and antibacterial properties [J].

Bakhsheshi-Rad, H. R. ;

Chen, X. B. ;

Ismail, A. F. ;

Aziz, M. ;

Hamzah, E. ;

Najafinezhad, A. .

MATERIALS CHEMISTRY AND PHYSICS, 2019, 222 :118-131

[2] Drug release, cytocompatibility, bioactivity, and antibacterial activity of doxycycline loaded Mg-Ca-TiO2 composite scaffold [J].

Bakhsheshi-Rad, H. R. ;

Hamzah, E. ;

Staiger, Mark P. ;

Dias, George J. ;

Hadisi, Z. ;

Saheban, M. ;

Kashefian, M. .

MATERIALS & DESIGN, 2018, 139 :212-221

[3] Osteoconductive and Osteoinductive Properties of Zeolite MFI Coatings on Titanium Alloys [J].

Bedi, Rajwant S. ;

Zanello, Laura P. ;

Yan, Yushan .

ADVANCED FUNCTIONAL MATERIALS, 2009, 19 (24) :3856-3861

[4] Bioactive Materials for Regenerative Medicine: Zeolite-Hydroxyapatite Bone Mimetic Coatings [J].

Bedi, Rajwant Singh ;

Chow, Gabriel ;

Wang, Junlan ;

Zanello, Laura ;

Yan, Yushan S. .

ADVANCED ENGINEERING MATERIALS, 2012, 14 (03) :200-206

[5] Controlled release of drug from folate-decorated and graphene mediated drug delivery system: Synthesis, loading efficiency, and drug release response [J].

Depan, D. ;

Shah, J. ;

Misra, R. D. K. .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2011, 31 (07) :1305-1312

[6] Structure-process-property relationship of the polar graphene oxide-mediated cellular response and stimulated growth of osteoblasts on hybrid chitosan network structure nanocomposite scaffolds [J].

Depan, D. ;

Girase, B. ;

Shah, J. S. ;

Misra, R. D. K. .

ACTA BIOMATERIALIA, 2011, 7 (09) :3432-3445

[7] Antimicrobial activity of faujasite zeolites doped with silver [J].

Ferreira, Liliana ;

Fonseca, Antonio M. ;

Botelho, Gabriela ;

Almeida-Aguiar, Cristina ;

Neves, Isabel C. .

MICROPOROUS AND MESOPOROUS MATERIALS, 2012, 160 :126-132

[8] Cellular Mechanics of Modulated Osteoblasts Functions in Graphene Oxide Reinforced Elastomers [J].

Girase, Bhupendra ;

Shah, Jinesh S. ;

Misra, R. Devesh K. .

ADVANCED ENGINEERING MATERIALS, 2012, 14 (04) :B101-B111

[9] Biointerface by Cell Growth on Layered Graphene-Artificial Peroxidase-Protein Nanostructure for In Situ Quantitative Molecular Detection [J].

Guo, Chun Xian ;

Zheng, Xin Ting ;

Lu, Zhi Song ;

Lou, Xiong Wen ;

Li, Chang Ming .

ADVANCED MATERIALS, 2010, 22 (45) :5164-+

[10] Evaluation of the resistance of mortars coated with silver bearing zeolite to bacterial-induced corrosion [J].

Halle, Tesfaalem ;

Nakhla, George ;

Allouche, Erez .

CORROSION SCIENCE, 2008, 50 (03) :713-720

← 1 2 3 →