Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

被引：66

作者：

Haagmans, Bart L. ^{[1
]}

van den Brand, Judith M. A. ^{[1
]}

Provacia, Lisette B. ^{[1
]}

Raj, V. Stalin ^{[1
]}

Stittelaar, Koert J. ^{[2
]}

Getu, Sarah ^{[1
]}

de Waal, Leon ^{[2
]}

Bestebroer, Theo M. ^{[1
]}

van Amerongen, Geert ^{[1
]}

Verjans, Georges M. G. M. ^{[1
]}

Fouchier, Ron A. M. ^{[1
]}

Smits, Saskia L. ^{[1
,2
]}

Kuiken, Thijs ^{[1
]}

Osterhaus, Albert D. M. E. ^{[1
,2
]}

机构：

[1] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[2] Viroclin Biosci, Rotterdam, Netherlands

来源：

JOURNAL OF VIROLOGY | 2015年 / 89卷 / 11期

关键词：

MOUSE MODEL; GENERATION;

D O I：

10.1128/JVI.00661-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.

引用

页码：6131 / 6135

页数：5

共 16 条

[1] Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease [J].

Agrawal, Anurodh Shankar ;

Garron, Tania ;

Tao, Xinrong ;

Peng, Bi-Hung ;

Wakamiya, Maki ;

Chan, Teh-Sheng ;

Couch, Robert B. ;

Tseng, Chien-Te K. .

JOURNAL OF VIROLOGY, 2015, 89 (07) :3659-3670

[2]

Alagaili AN, 2014, MBIO, V5, DOI [10.1128/mBio.00884-14, 10.1128/mBio.01482-14]

[3]

Bermingham A, 2012, EUROSURVEILLANCE, V17, P6

[4] Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus [J].

Coleman, Christopher M. ;

Matthews, Krystal L. ;

Goicochea, Lindsay ;

Frieman, Matthew B. .

JOURNAL OF GENERAL VIROLOGY, 2014, 95 :408-412

[5]

Corman VM, 2012, EUROSURVEILLANCE, V17, P3

[6] Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques [J].

de Wit, Emmie ;

Rasmussen, Angela L. ;

Falzarano, Darryl ;

Bushmaker, Trenton ;

Feldmann, Friederike ;

Brining, Douglas L. ;

Fischer, Elizabeth R. ;

Martellaro, Cynthia ;

Okumura, Atsushi ;

Chang, Jean ;

Scott, Dana ;

Benecke, Arndt G. ;

Katze, Michael G. ;

Feldmann, Heinz ;

Munster, Vincent J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (41) :16598-16603

[7] The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters [J].

de Wit, Emmie ;

Prescott, Joseph ;

Baseler, Laura ;

Bushmaker, Trenton ;

Thomas, Tina ;

Lackemeyer, Matthew G. ;

Martellaro, Cynthia ;

Milne-Price, Shauna ;

Haddock, Elaine ;

Haagmans, Bart L. ;

Feldmann, Heinz ;

Munster, Vincent J. .

PLOS ONE, 2013, 8 (07)

[8] Replicative Capacity of MERS Coronavirus in Livestock Cell Lines [J].

Eckerle, Isabella ;

Corman, Victor M. ;

Mueller, Marcel A. ;

Lenk, Matthias ;

Ulrich, Rainer G. ;

Drosten, Christian .

EMERGING INFECTIOUS DISEASES, 2014, 20 (02) :276-279

[9] Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation [J].

Haagmans, Bart L. ;

Al Dhahiry, Said H. S. ;

Reusken, Chantal B. E. M. ;

Raj, V. Stalin ;

Galiano, Monica ;

Myers, Richard ;

Godeke, Gert-Jan ;

Jonges, Marcel ;

Farag, Elmoubasher ;

Diab, Ayman ;

Ghobashy, Hazem ;

Alhajri, Farhoud ;

Al-Thani, Mohamed ;

Al-Marri, Salih A. ;

Al Romaihi, Hamad E. ;

Al Khal, Abdullatif ;

Bermingham, Alison ;

Osterhaus, Albert D. M. E. ;

AlHajri, Mohd M. ;

Koopmans, Marion P. G. .

LANCET INFECTIOUS DISEASES, 2014, 14 (02) :140-145

[10] Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capability in Mammalian Cell Lines [J].

Mueller, Marcel A. ;

Raj, V. Stalin ;

Muth, Doreen ;

Meyer, Benjamin ;

Kallies, Stephan ;

Smits, Saskia L. ;

Wollny, Robert ;

Bestebroer, Theo M. ;

Specht, Sabine ;

Suliman, Tasnim ;

Zimmermann, Katrin ;

Binger, Tabea ;

Eckerle, Isabella ;

Tschapka, Marco ;

Zaki, Ali M. ;

Osterhaus, Albert D. M. E. ;

Fouchier, Ron A. M. ;

Haagmans, Bart L. ;

Drosten, Christian .

MBIO, 2012, 3 (06)

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