Influence of treatments in multiple sclerosis disability: A cohort study

被引：31

作者：

Cocco, Eleonora ^{[1
,2
]}

Sardu, Claudia ^{[1
]}

Spinicci, Gabriella ^{[2
]}

Musu, Luigina ^{[2
]}

Massa, Rita ^{[2
]}

Frau, Jessica ^{[1
,2
]}

Lorefice, Lorena ^{[1
,2
]}

Fenu, Giuseppe ^{[1
,2
]}

Coghe, Giancarlo ^{[1
,2
]}

Massole, Serenella ^{[2
]}

Maioli, Maria Antonietta ^{[2
]}

Piras, Rachele ^{[1
,2
]}

Melis, Marta ^{[1
,2
]}

Porcu, Gianluca ^{[2
]}

Mamusa, Elena ^{[2
]}

Carboni, Nicola ^{[2
]}

Contu, Paolo ^{[1
]}

Marrosu, Maria Giovanna ^{[1
,2
]}

机构：

[1] Univ Cagliari, I-09126 Cagliari, Italy

[2] ASL 8, MS Ctr, Cagliari, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2015年 / 21卷 / 04期

关键词：

Multiple sclerosis; disability; treatment; immunomodulant; immunosuppressant; SECONDARY PROGRESSIVE MS; LONG-TERM DISABILITY; NATURAL-HISTORY; DIAGNOSTIC-CRITERIA; INTERFERON-BETA; TIME; GUIDELINES; BENEFIT; DRUGS; TRIAL;

D O I：

10.1177/1352458514546788

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and objective: A critical aspect of multiple sclerosis (MS) treatments is understanding the effect of disease-modifying drugs (DMDs) on the long-term risk of disability and whether the effect is related to disability at start of treatment. Methods: We performed an observational study on 3060 MS patients. The effect of therapy on progression to Expanded Disability Status Scale (EDSS) 3.0 and 6.0 from onset was analysed in treated vs untreated (UTP) patients using Cox regression analysis adjusted for propensity score and immortal time bias. Results: Compared to UTP, the risks of EDSS 3.0 were 94% and 73% lower in immunomodulant (IMTP-) and immunosuppressant (ISTP-) treated patients, respectively, while the risk of EDSS 6.0 was 86% lower in IMTP. The risk of EDSS 6.0 was, respectively, 91% and 75% lower in 1275 IMTP before and 114 after EDSS 3.0 than in 539 UTP; the risk was higher in IMTP starting therapy after EDSS 3.0 than before (HR = 4.42). Conclusions: DMDs delayed long-term disability in MS patients treated either in the early or, to a lesser extent, in the later phase of the disease. Thus, the window of therapeutic opportunity is relatively extended, assuming that early is better than late treatment, but late is better than never.

引用

页码：433 / 441

页数：9

共 35 条

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