Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population

被引：53

作者：

Shen, Qin ^{[1
,2
]}

Zhang, Zhou ^{[2
]}

Yu, Lan ^{[2
]}

Cao, Lan ^{[1
]}

Zhou, DaiZhan ^{[2
]}

Kan, MengYuan ^{[2
]}

Li, Baojie ^{[3
]}

Zhang, Di ^{[2
]}

He, Lin ^{[1
,2
,3
]}

Liu, Yun ^{[1
]}

机构：

[1] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Bio X Ctr, Key Lab Dev Genet & Neuropsychiat Dis, Minist Educ, Shanghai 200030, Peoples R China

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2011年 / 19卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Chinese population; TERC; leukocyte telomere length; HUMANS; LOCI;

D O I：

10.1038/ejhg.2011.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent genome-wide association study has identified an association between leukocyte telomere length (LTL) and a locus at 3q26 that includes TERC. In order to evaluate the effects of the SNPs rs12696304 and rs16847897 near TERC in the population of mainland China, we conducted an association study of LTL focusing on these two candidate SNPs in a sample of 4016 Chinese Han individuals. Multiple linear regression analyses were performed to evaluate the association of LTL with each SNP adjusted for age, gender and diabetes status. In the study, we confirmed the association of SNP rs12696304 and rs16847897 near TERC with LTL in the Chinese Han population (P similar to 4.5 x 10(-3) and 9.5x10(-5), respectively). Each copy of the major allele of rs12696304 and rs16847897 was associated with a shorter mean telomere length of 0.024 and 0.031 T/S respectively, which is equivalent to about 3 and 4 years of average age-related telomere attrition. Our short report confirmed the effects of SNPs near TERC on LTL in the Chinese Han population for the first time. European Journal of Human Genetics (2011) 19, 721-723; doi:10.1038/ejhg.2011.4; published online 9 February 2011

引用

页码：721 / 723

页数：3

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