The way of SARS-CoV-2 vaccine development: success and challenges

被引:40
作者
Dong, Yetian [1 ,2 ,3 ,4 ]
Dai, Tong [5 ,6 ]
Wang, Bin [2 ,3 ]
Zhang, Lei [4 ]
Zeng, Ling-Hui [1 ]
Huang, Jun [2 ,3 ]
Yan, Haiyan [1 ]
Zhang, Long [2 ,3 ]
Zhou, Fangfang [5 ,6 ]
机构
[1] Zhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
[2] Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China
[3] Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 3, Ruian, Peoples R China
[5] Soochow Univ, Inst Biol, Suzhou 215123, Peoples R China
[6] Soochow Univ, Inst Med Sci, Suzhou 215123, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
RECEPTOR-BINDING DOMAIN; NEUTRALIZING ANTIBODIES; POPULATION-LEVEL; COVID-19; VACCINE; SPIKE; VARIANT; SAFETY; IMMUNOGENICITY; CORONAVIRUS; INFECTION;
D O I
10.1038/s41392-021-00796-w
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rollout worldwide. With novel SARS-CoV-2 variants emerging and circulating widely, whether the original vaccines that were designed based on the wild-type SARS-CoV-2 were effective against these variants has been a contentious discussion. Moreover, some studies revealed the long-term changes of immune responses post SARS-CoV-2 infection or vaccination and the factors that might impact the vaccine-induced immunity. Thus, in this review, we have summarized the influence of mutational hotspots on the vaccine efficacy and characteristics of variants of interest and concern. We have also discussed the reasons that might result in discrepancies in the efficacy of different vaccines estimated in different trials. Furthermore, we provided an overview of the duration of immune responses after natural infection or vaccination and shed light on the factors that may affect the immunity induced by the vaccines, such as special disease conditions, sex, and pre-existing immunity, with the aim of aiding in combating COVID-19 and distributing SARS-CoV-2 vaccines under the prevalence of diverse SARS-CoV-2 variants.
引用
收藏
页数:14
相关论文
共 170 条
[21]   Disappearance of antibodies to SARS-associated coronavirus after recovery [J].
Cao, Wu-Chun ;
Liu, Wei ;
Zhang, Pan-He ;
Zhang, Fang ;
Richardus, Jan H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (11) :1162-1163
[22]   Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study [J].
Challen, Robert ;
Brooks-Pollock, Ellen ;
Read, Jonathan M. ;
Dyson, Louise ;
Tsaneva-Atanasova, Krasimira ;
Danon, Leon .
BMJ-BRITISH MEDICAL JOURNAL, 2021, 372
[23]   A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [J].
Chan, Jasper Fuk-Woo ;
Yuan, Shuofeng ;
Kok, Kin-Hang ;
To, Kelvin Kai-Wang ;
Chu, Hin ;
Yang, Jin ;
Xing, Fanfan ;
Liu, Jieling ;
Yip, Cyril Chik-Yan ;
Poon, Rosana Wing-Shan ;
Tsoi, Hoi-Wah ;
Lo, Simon Kam-Fai ;
Chan, Kwok-Hung ;
Poon, Vincent Kwok-Man ;
Chan, Wan-Mui ;
Ip, Jonathan Daniel ;
Cai, Jian-Piao ;
Cheng, Vincent Chi-Chung ;
Chen, Honglin ;
Hui, Christopher Kim-Ming ;
Yuen, Kwok-Yung .
LANCET, 2020, 395 (10223) :514-523
[24]   Serum neutralising activity against SARS-CoV-2 variants elicited by CoronaVac [J].
Chen, Yuxin ;
Shen, Han ;
Huang, Rui ;
Tong, Xin ;
Wu, Chao .
LANCET INFECTIOUS DISEASES, 2021, 21 (08) :1071-1072
[25]  
Choi A., NAT MED, DOI [10.1038/s41591-021-01527-y(2021, DOI 10.1038/S41591-021-01527-Y(2021]
[26]   Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women [J].
Collier, Ai-ris Y. ;
McMahan, Katherine ;
Yu, Jingyou ;
Tostanoski, Lisa H. ;
Aguayo, Ricardo ;
Ansel, Jessica ;
Chandrashekar, Abishek ;
Patel, Shivani ;
Apraku Bondzie, Esther ;
Sellers, Daniel ;
Barrett, Julia ;
Sanborn, Owen ;
Wan, Huahua ;
Chang, Aiquan ;
Anioke, Tochi ;
Nkolola, Joseph ;
Bradshaw, Connor ;
Jacob-Dolan, Catherine ;
Feldman, Jared ;
Gebre, Makda ;
Borducchi, Erica N. ;
Liu, Jinyan ;
Schmidt, Aaron G. ;
Suscovich, Todd ;
Linde, Caitlyn ;
Alter, Galit ;
Hacker, Michele R. ;
Barouch, Dan H. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (23) :2370-2380
[27]   Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies [J].
Collier, Dami A. ;
De Marco, Anna ;
Ferreira, Isabella A. T. M. ;
Meng, Bo ;
Datir, Rawlings P. ;
Walls, Alexandra C. ;
Kemp, Steven A. ;
Bassi, Jessica ;
Pinto, Dora ;
Silacci-Fregni, Chiara ;
Bianchi, Siro ;
Tortorici, M. Alejandra ;
Bowen, John ;
Culap, Katja ;
Jaconi, Stefano ;
Cameroni, Elisabetta ;
Snell, Gyorgy ;
Pizzuto, Matteo S. ;
Pellanda, Alessandra Franzetti ;
Garzoni, Christian ;
Riva, Agostino ;
Elmer, Anne ;
Kingston, Nathalie ;
Graves, Barbara ;
Mccoy, Laura E. ;
Smith, Kenneth G. C. ;
Bradley, John R. ;
Temperton, Nigel ;
Ceron-Gutierrez, Lourdes ;
Barcenas-Morales, Gabriela ;
Harvey, William ;
Virgin, Herbert W. ;
Lanzavecchia, Antonio ;
Piccoli, Luca ;
Doffinger, Rainer ;
Wills, Mark ;
Veesler, David ;
Corti, Davide ;
Gupta, Ravindra K. .
NATURE, 2021, 593 (7857) :136-+
[28]   Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2 [J].
Collier, Dami A. ;
Ferreira, Isabella A. T. M. ;
Kotagiri, Prasanti ;
Datir, Rawlings P. ;
Lim, Eleanor Y. ;
Touizer, Emma ;
Meng, Bo ;
Abdullahi, Adam ;
Elmer, Anne ;
Kingston, Nathalie ;
Graves, Barbara ;
Le Gresley, Emma ;
Caputo, Daniela ;
Bergamaschi, Laura ;
Smith, Kenneth G. C. ;
Bradley, John R. ;
Ceron-Gutierrez, Lourdes ;
Cortes-Acevedo, Paulina ;
Barcenas-Morales, Gabriela ;
Linterman, Michelle A. ;
McCoy, Laura E. ;
Davis, Chris ;
Thomson, Emma ;
Lyons, Paul A. ;
McKinney, Eoin ;
Doffinger, Rainer ;
Wills, Mark ;
Gupta, Ravindra K. .
NATURE, 2021, 596 (7872) :417-+
[29]   BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting [J].
Dagan, Noa ;
Barda, Noam ;
Kepten, Eldad ;
Miron, Oren ;
Perchik, Shay ;
Katz, Mark A. ;
Hernan, Miguel A. ;
Lipsitch, Marc ;
Reis, Ben ;
Balicer, Ran D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (15) :1412-1423
[30]   Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection [J].
Dan, Jennifer M. ;
Mateus, Jose ;
Kato, Yu ;
Hastie, Kathryn M. ;
Yu, Esther Dawen ;
Faliti, Caterina E. ;
Grifoni, Alba ;
Ramirez, Sydney, I ;
Haupt, Sonya ;
Frazier, April ;
Nakao, Catherine ;
Rayaprolu, Vamseedhar ;
Rawlings, Stephen A. ;
Peters, Bjoern ;
Krammer, Florian ;
Simon, Viviana ;
Saphire, Erica Ollmann ;
Smith, Davey M. ;
Weiskopf, Daniela ;
Sette, Alessandro ;
Crotty, Shane .
SCIENCE, 2021, 371 (6529) :587-+