Synthesis and characterization of curcumin-incorporated glycopolymers with enhanced water solubility and reduced cytotoxicity

被引：3

作者：

Zhang, Haisong ^{[1
,2
]}

Ren, Tianci ^{[1
]}

Yu, Meng ^{[2
]}

Zhang, Hailei ^{[1
]}

Bai, Libin ^{[1
]}

Wu, Yonggang ^{[1
]}

Wang, Sujuan ^{[1
]}

Ba, Xinwu ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China

[2] Hebei Univ, Affiliated Hosp, Baoding 071000, Peoples R China

来源：

MACROMOLECULAR RESEARCH | 2016年 / 24卷 / 08期

基金：

中国国家自然科学基金;

关键词：

curcumin; glycopolymer; cell imaging; biocompatibility; ANTIOXIDANT CURCUMIN; PHOTODYNAMIC THERAPY; ORAL BIOAVAILABILITY; CANCER-CELLS; DELIVERY; CYCLODEXTRIN; CONJUGATE; STABILITY; DISEASE; ANALOGS;

D O I：

10.1007/s13233-016-4095-4

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Curcumin is the physiologically and pharmacologically active component of turmeric (Curcuma longa L.) with attractive fluorescent property. However, the applications in live cell imaging field are restricted mainly due to the water-insolubility and cytotoxicity. To overcome this problem, curcumin-incorporated glycopolymers are synthesized by free radical copolymerization in this study. The glycopolymers are well-characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), UV-Vis absorption spectroscopy and photoluminescence spectroscopy. Furthermore, obtained glycopolymers are assayed by MTT assay and cell imaging for supporting the potential bio application. The MTT result indicates that the introduction of carbohydrate units can reduce the cytotoxicity of curcumin unit. The live cell imaging investigations reveal that the curcuminincorporated glycopolymers are good candidates for cell imaging and may find broad applications in biological areas such as biological diagnosis, imaging, and detection.

引用

页码：655 / 662

页数：8

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