Synthesis and Biological Evaluation of New Chromenes and Chromeno[2,3-d] pyrimidines

被引：6

作者：

Belhadj, Fatima ^{[1
,2
]}

Kibou, Zahira ^{[1
,4
]}

Benabdallah, Mohammed ^{[1
]}

Aissaoui, Mohammed ^{[5
]}

Rahmoun, Mohammed Nadjib ^{[5
]}

Villemin, Didier ^{[3
]}

Choukchou-Braham, Noureddine ^{[1
]}

机构：

[1] Univ Tlemcen, Lab Catalyse & Synthise Chim Organ, Fac Sci, BP 119, Tilimsen, Algeria

[2] Univ Oran 1, Fac Med, BP 1510 ELMENAOUAR, Oran 31000, Algeria

[3] LCMT, ENSICAEN, UMR CNRS 6507, 6 Bd Marechal Juin, F-14050 Caen, France

[4] Univ Ain Temouchent, Fac Sci & Technol, BP 284, Ain Temouchent 46000, Algeria

[5] Univ Tlemcen, Fac SNV STU, Lab Antibiot Antifong Phys Chim Synth & Activite, Tilimsen 13000, Algeria

来源：

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2021年 / 75卷

关键词：

5H-chromeno[2; 3-d] pyrimidine; 4H-chromene; solvent-free conditions; antioxidant activity; antibacterial activity; EFFICIENT SYNTHESIS; DERIVATIVES;

D O I：

10.17159/0379-4350/2021/v75a18

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient approach has been developed to synthesise novel and functionalised 5H-chromeno[2,3-d] pyrimidines derivatives (4a-h). This approach entails treating 2-amino-3-cyano-4H-chromenes (3a-h) with formamidine acetate under microwave irradiations and solvent-free conditions. All structures of new compounds obtained in this study were characterised by IR, MS, 1H and 13C NMR analysis. Additionally, the synthesised compounds were investigated for their antibacterial and antioxidant potential. Compounds 3b, 3c, 3e, 4c and 4e showed significant activities.

引用

页码：150 / 155

页数：6

共 33 条

[1] Synthesis, Reactions and Evaluation of the Antimicrobial Activity of Some 4-(p-Halophenyl)-4H-naphthopyran, Pyranopyrimidine and Pyranotriazolopyrimidine Derivatives [J].

Abd El-Wahab, Ashraf H. F. .

PHARMACEUTICALS, 2012, 5 (07) :745-757

[2]

Albadi J, 2013, J NANOSTRUCTURE CHEM, V3

[3]

Barek Said, 2020, Journal of Herbs, Spices & Medicinal Plants, V26, P1, DOI 10.1080/10496475.2019.1661327

[4] Convenient access to new 4-substituted aminopyrido[2,3-d]pyrimidine derivatives [J].

Belhadj, Fatima ;

Kibou, Zahira ;

Cheikh, Nawel ;

Choukchou-Braham, Noureddine ;

Villemin, Didier .

TETRAHEDRON LETTERS, 2015, 56 (44) :5999-6002

[5] Advances in Spirocyclic Hybrids: Chemistry and Medicinal Actions [J].

Benadallah, Mohammed ;

Talhi, Oualid ;

Nouali, Fatiha ;

Choukchou-Braham, Nouredine ;

Bachari, Khaldoun ;

Silva, Artur M. S. .

CURRENT MEDICINAL CHEMISTRY, 2018, 25 (31) :3748-3767

[6] Improved synthesis of substituted pyrido[2,3-d]pyrimidinediones [J].

Churchill, Gwydion H. ;

Raw, Steven A. ;

Powell, Lyn .

TETRAHEDRON LETTERS, 2011, 52 (28) :3657-3661

[7]

Desale KR, 2012, ORG COMMUN, V5, P179

[8] Synthesis of Benzo[f]chromeno[2,3-d]pyrimidines via the Tandem Intramolecular Pinner/Dimroth Rearrangement and their Antibacterial and Antioxidant Evaluation [J].

Ebrahimi, Zohreh ;

Davoodnia, Abolghasem ;

Motavalizadehkakhky, Alireza ;

Mehrzad, Jamshid .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2019, 51 (04) :357-367

[9] SYNTHESIS AND CNS-ACTIVITY OF PYRAN DERIVATIVES - 6,8-DIOXABICYCLO[3,2,1]OCTANES .133. [J].

EIDEN, F ;

DENK, F .

ARCHIV DER PHARMAZIE, 1991, 324 (06) :353-354

[10] Synthesis and antimicrobial activities of 2-substituted 12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines, 3-ethoxycarbonyl-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-one and ethyl 2-formylamino- and 2-acetylamino-4H-chromene-3-carboxylates [J].

El-Agrody, Ahmed M. ;

Sabry, Nermien M. ;

Motlaq, Shymaa S. .

JOURNAL OF CHEMICAL RESEARCH, 2011, (02) :77-83

← 1 2 3 4 →