Novel anti-microbial host-guest complexes based on cationic β-cyclodextrin polymers and triclosan/butylparaben

The preparation of novel cationic beta-cyclodextrin polymers (CP beta Ms) and its complexes with butylparaben and triclosan were reported in this paper. FT-IR and two-dimensional (2D) H-1-H-1 gradient correlated spectroscopy (gCOSY) NMR spectra confirmed that the antibiotics could be included inside the lipophilic cavities of CP beta CDs. The water solubility of the antibiotics was improved significantly after cl inclusion with CP beta CDs. The results also suggest that it was easier for butylparaben, which had relatively small molecular size, to form the complexes with CP beta CDs than triclo san. Due to the targeting effect after the inclusion with cationic CP beta CDs, the anti-microbial activity of butylparaben was also enhanced substantially. However, similar im provement was not obvious for triclosan.