Single nucleotide polymorphisms within the promoter region of the rhesus monkey tumor necrosis factor-alpha gene

被引：5

作者：

Singh, KK ^{[1
]}

Schmidtke, J ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Human Genet, D-30625 Hannover, Germany

来源：

IMMUNOGENETICS | 2005年 / 57卷 / 3-4期

关键词：

tumor necrosis factor-alpha (TNF-alpha); single nucleotide polymorphisms (SNPs); animal model; rhesus monkey;

D O I：

10.1007/s00251-005-0799-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The human TNF-alpha gene is characterized by several single nucleotide polymorphisms (SNPs) in its promoter region, in part having been shown to influence TNF-alpha expression and susceptibility to various diseases. The rhesus macaque is widely used as an animal model for a variety of TNF-alpha associated pathological conditions, but little is known about genetic variation within the TNF-alpha promoter region. In order to check for such polymorphisms, primers based on rhesus sequence within 5' UTR were designed and used to amplify a similar to 1 kb product from genomic DNA of 29 animals. Sequencing and cloning revealed a total of 11 polymorphisms leading to five different haplotypes.

引用

页码：289 / 292

页数：4

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