Biosynthesis of Nitrogenase Cofactors

被引：158
作者：
Buren, Stefan [1 ]
Jimenez-Vicente, Emilio [2 ]
Echavarri-Erasun, Carlos [1 ]
Rubio, Luis M. [1 ]
机构：
[1] Univ Politecn Madrid UPM, Ctr Biotecnol & Genom Plantas, Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Madrid 28223, Spain
[2] Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA
来源：
CHEMICAL REVIEWS | 2020年 / 120卷 / 12期
基金：
比尔及梅琳达.盖茨基金会;
关键词：
IRON-MOLYBDENUM COFACTOR; KLEBSIELLA-PNEUMONIAE NITROGENASE; IN-VITRO SYNTHESIS; CONSERVED CYSTEINE RESIDUES; VINELANDII MUTANT STRAINS; FERREDOXIN-LIKE PROTEIN; MO STORAGE PROTEIN; FEMO-CO PRECURSOR; AZOTOBACTER-VINELANDII; SULFUR CLUSTER;
D O I：
10.1021/acs.chemrev.9b00489
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nitrogenase harbors three distinct metal prosthetic groups that are required for its activity. The simplest one is a [4Fe-4S] cluster located at the Fe protein nitrogenase component. The MoFe protein component carries an [8Fe-7S] group called P-cluster and a [7Fe-9S-C-Mo-R-homocitrate] group called FeMo-co. Formation of nitrogenase metalloclusters requires the participation of the structural nitrogenase components and many accessory proteins, and occurs both in situ, for the P-cluster, and in external assembly sites for FeMo-co. The biosynthesis of FeMo-co is performed stepwise and involves molecular scaffolds, metallochaperones, radical chemistry, and novel and unique biosynthetic intermediates. This review provides a critical overview of discoveries on nitrogenase cofactor structure, function, and activity over the last four decades.
引用
收藏
页码：4921 / 4968
页数：48
相关论文
共 250 条
[1]   Modular organization and identification of a mononuclear iron-binding site within the NifU protein [J].
Agar, JN ;
Yuvaniyama, P ;
JAck, RF ;
Cash, VL ;
Smith, AD ;
Dean, DR ;
Johnson, MK .
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2000, 5 (02) :167-177
[2]   IscU as a scaffold for iron-sulfur cluster biosynthesis: Sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU [J].
Agar, JN ;
Krebs, C ;
Frazzon, J ;
Huynh, BH ;
Dean, DR ;
Johnson, MK .
BIOCHEMISTRY, 2000, 39 (27) :7856-7862
[3]   Incorporation of molybdenum into the iron-molybdenum cofactor of nitrogenase [J].
Allen, RM ;
Roll, JT ;
Rangaraj, P ;
Shah, VK ;
Roberts, GP ;
Ludden, PW .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (22) :15869-15874
[4]  
ALLEN RM, 1993, J BIOL CHEM, V268, P23670
[5]   INCORPORATION OF IRON AND SULFUR FROM NIFB COFACTOR INTO THE IRON-MOLYBDENUM COFACTOR OF DINITROGENASE [J].
ALLEN, RM ;
CHATTERJEE, R ;
LUDDEN, PW ;
SHAH, VK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :26890-26896
[6]   Expression of 16 Nitrogenase Proteins within the Plant Mitochondrial Matrix [J].
Allen, Robert S. ;
Tilbrook, Kimberley ;
Warden, Andrew C. ;
Campbell, Peter C. ;
Rolland, Vivien ;
Singh, Surinder P. ;
Wood, Craig C. .
FRONTIERS IN PLANT SCIENCE, 2017, 8 :1-14
[7]   Diversity and Functional Analysis of the FeMo-Cofactor Maturase NifB [J].
Arragain, Simon ;
Jimenez-Vicente, Emilio ;
Scandurra, Alessandro A. ;
Buren, Stefan ;
Rubio, Luis M. ;
Echavarri-Erasun, Carlos .
FRONTIERS IN PLANT SCIENCE, 2017, 8
[8]   Uptake of molybdenum and vanadium by a nitrogen-fixing soil bacterium using siderophores [J].
Bellenger, J. P. ;
Wichard, T. ;
Kustka, A. B. ;
Kraepiel, A. M. L. .
NATURE GEOSCIENCE, 2008, 1 (04) :243-246
[9]   COMPARATIVE ORGANIZATION OF NITROGEN FIXATION-SPECIFIC GENES FROM AZOTOBACTER-VINELANDII AND KLEBSIELLA-PNEUMONIAE - DNA-SEQUENCE OF THE NIFUSV GENES [J].
BEYNON, J ;
ALLY, A ;
CANNON, M ;
CANNON, F ;
JACOBSON, M ;
CASH, V ;
DEAN, D .
JOURNAL OF BACTERIOLOGY, 1987, 169 (09) :4024-4029
[10]   Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotes [J].
Biegel, Eva ;
Schmidt, Silke ;
Gonzalez, Jose M. ;
Mueller, Volker .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (04) :613-634
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