MicroRNA history: Discovery, recent applications, and next frontiers

被引:314
作者
Almeida, Maria I. [1 ,2 ,3 ]
Reis, Rui M. [3 ,4 ]
Calin, George A. [1 ,2 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNAs, Houston, TX 77030 USA
[3] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal
[4] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, S Paulo, Brazil
关键词
MicroRNAs; History; Cancer; MESSENGER-RNA TRANSLATION; HETEROCHRONIC GENE LIN-14; POSTTRANSCRIPTIONAL REGULATION; RHEUMATOID-ARTHRITIS; DOWN-REGULATION; NONCODING RNAS; TUMOR INVASION; BINDING-SITES; CELL LINEAGES; IN-VIVO;
D O I
10.1016/j.mrfmmm.2011.03.009
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Since 1993, when the first small non-coding RNA was identified, our knowledge about microRNAs has grown exponentially. In this review, we focus on the main progress in this field and discuss the most important findings under a historical perspective. In addition, we examine microRNAs as markers of disease diagnosis and prognosis, and as new therapeutic targets. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 8
页数:8
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