Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1

被引：8

作者：

Hellmund, Chris ^{[1
]}

Lever, Andrew M. L. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med, Cambridge CB2 0QQ, England

来源：

VIRUSES-BASEL | 2016年 / 8卷 / 07期

基金：

英国医学研究理事会;

关键词：

HIV-1; RNA; packaging; assembly; IMMUNODEFICIENCY-VIRUS TYPE-1; DIMERIZATION INITIATION SITE; NUCLEAR EXPORT ELEMENTS; DNA-CONTAINING VIRUS; IN-VITRO; PLASMA-MEMBRANE; STRUCTURAL SWITCH; DELETION MUTAGENESIS; GAG POLYPROTEIN; LEADER RNA;

D O I：

10.3390/v8070192

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The tremendous progress made in unraveling the complexities of human immunodeficiency virus (HIV) replication has resulted in a library of drugs to target key aspects of the replication cycle of the virus. Yet, despite this accumulated wealth of knowledge, we still have much to learn about certain viral processes. One of these is virus assembly, where the viral genome and proteins come together to form infectious progeny. Here we review this topic from the perspective of how the route to production of an infectious virion is orchestrated by the viral genome, and we compare and contrast aspects of the assembly mechanisms employed by HIV-1 with those of other RNA viruses.

引用

页数：13

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