Leveraging the Gut to Treat Metabolic Disease

被引：56

作者：

Gimeno, Ruth E. ^{[1
]}

Briere, Daniel A. ^{[1
]}

Seeley, Randy J. ^{[2
]}

机构：

[1] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46225 USA

[2] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

来源：

CELL METABOLISM | 2020年 / 31卷 / 04期

关键词：

GLUCAGON-LIKE PEPTIDE-1; PROTEIN-COUPLED RECEPTOR; Y GASTRIC BYPASS; DEPENDENT INSULINOTROPIC POLYPEPTIDE; TYPE-2; DIABETES-MELLITUS; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; VERTICAL SLEEVE GASTRECTOMY; BILE-ACID RECEPTOR; REDUCE FOOD-INTAKE; WEIGHT-LOSS;

D O I：

10.1016/j.cmet.2020.02.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

25 years ago, the suture of treating obes and diabetes focused on end organs known to be involved in energy balance and glucose regulation, including the brain, muscle, adipose tissue, and pancreas. Today. the most effective therapies are focused around the gut. This includes surgical options, such as vertical sleeve gastrectomy and Roux-en-Y gastric bypass, that can produce sustained weight loss and diabetes remission but also extends to pharmacological treatments that simulate or amplify various signals that come from the gut. The purpose of this Review is to discuss the wealth of approaches currently under development that seek to further leverage the gut as a source of novel therapeutic opportunities with the hope that we can achieve the effects of surgical interventions with less invasive and more scalable solutions.

引用

页码：679 / 698

页数：20

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