Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity

被引：36

作者：

Salah, SM ^{[1
]}

Jäger, AK ^{[1
]}

机构：

[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 99卷 / 01期

关键词：

Artemisia herba-alba; cirsilineol; GABA(A)-benzodiazepine receptor; hispidulin;

D O I：

10.1016/j.jep.2005.01.031

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An ethyl acetate extract of Artemisia herba-alba was partitioned by HPLC in 10 fractions that were tested in the [H-3]-flumazenil radioligand assay, for affinity to the GABA(A)-benzodiazepine receptor. Two fractions showed activity from which hispidulin and cirsilineol were isolated. The structures were confirmed by H-1 NMR. The IC50 values were 8 mu M for hispidulin and 100 mu M for cirsilineol. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：145 / 146

页数：2

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