Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA

被引：27

作者：

Wang, Peiqi ^{[1
]}

Hu, Jun ^{[2
,3
]}

Ghadermarzi, Shadi ^{[4
]}

Raza, Ali ^{[5
]}

O'Connell, Douglas ^{[6
]}

Xiao, Amy ^{[7
]}

Ayyaz, Faraz ^{[8
]}

Zhi, Min ^{[2
]}

Zhang, Yuanqi ^{[2
]}

Parekh, Nimisha K. ^{[6
]}

Lazarev, Mark ^{[9
]}

Parian, Alyssa ^{[9
]}

Brant, Steven R. ^{[10
]}

Bedine, Marshall ^{[9
]}

Truta, Brindusa ^{[9
]}

Hu, Pinjin ^{[2
]}

Banerjee, Rupa ^{[11
]}

Hutfless, Susan M. ^{[12
,13
]}

机构：

[1] Johns Hopkins Univ, Dept Surg, Baltimore, MD USA

[2] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastroenterol, Guangzhou, Guangdong, Peoples R China

[3] Sixth Affiliated Hosp, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou, Guangdong, Peoples R China

[4] East Carolina Univ, Dept Internal Med, Greenville, NC 27858 USA

[5] Harvard Med Sch, Boston Childrens Hosp, Dept Cardiol, Boston, MD USA

[6] Univ Calif Irvine, Sch Med, Div Gastroenterol, Irvine, CA 92717 USA

[7] Johns Hopkins Univ, Whiting Sch Engn, Dept Biomed Engn, Baltimore, MD USA

[8] Serv Inst Med Sci, Lahore, Pakistan

[9] Johns Hopkins Univ, Dept Med, Div Gastroenterol & Hepatol, Meyerhoff Inflammatory Bowel Dis Ctr, Baltimore, MD USA

[10] Univ Med & Dent New Jersey, Rutgers Hlth, Dept Med, Div Gastroenterol & Hepatol, New Brunswick, NJ USA

[11] Asian Inst Gastroenterol, Hyderabad, India

[12] Johns Hopkins Univ, Div Gastroenterol & Hepatol, Gastrointestinal Epidemiol Res Ctr, 600 N Wolfe St,Blalock 449, Baltimore, MD 21287 USA

[13] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2018年 / 63卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Smoking; Crohn's disease; Ulcerative colitis; Asia; Environment; CROHNS-DISEASE; ULCERATIVE-COLITIS; RISK-FACTORS; CIGARETTE-SMOKING; JEWISH PATIENTS; ASSOCIATION; EPIDEMIOLOGY; MULTICENTER; SUSCEPTIBILITY; POPULATION;

D O I：

10.1007/s10620-018-5142-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundCigarette smoking is thought to increase the risk of Crohn's disease (CD) and exacerbate the disease course, with opposite roles in ulcerative colitis (UC). However, these findings are from Western populations, and the association between smoking and inflammatory bowel disease (IBD) has not been well studied in Asia. AimsWe aimed to compare the prevalence of smoking at diagnosis between IBD cases and controls recruited in China, India, and the USA, and to investigate the impact of smoking on disease outcomes.MethodsWe recruited IBD cases and controls between 2014 and 2018. All participants completed a questionnaire about demographic characteristics, environmental risk factors and IBD history.ResultsWe recruited 337 participants from China, 194 from India, and 645 from the USA. In China, CD cases were less likely than controls to be current smokers (adjusted odds ratio [95% CI] 0.4 [0.2-0.9]). There was no association between current or former smoking and CD in the USA. In China and the USA, UC cases were more likely to be former smokers than controls (China 14.6 [3.3-64.8]; USA 1.8 [1.0-3.3]). In India, both CD and UC had similar current smoking status to controls at diagnosis. Current smoking at diagnosis was significantly associated with greater use of immunosuppressants (4.4 [1.1-18.1]) in CD cases in China.ConclusionsWe found heterogeneity in the associations of smoking and IBD risk and outcomes between China, India, and the USA. Further study with more adequate sample size and more uniform definition of smoking status is warranted.

引用

页码：2703 / 2713

页数：11

共 40 条

[1] MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].