TCF: transcriptional activator or repressor?

被引：120
作者：
Bienz, M [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 03期
关键词：
D O I：
10.1016/S0955-0674(98)80013-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
T cell factor, or TCF, has been identified as the transcriptional response factor activated by Wnt-1 and Wingless signalling. TCF is thought to be a potent architectural factor which facilitates assembly of multiprotein enhancer complexes. Its deregulation in the colonic epithelium, and in other cells, leads to cancer. This raises the question of how TCF is kept inactive in unstimulated cells.
引用
收藏
页码：366 / 372
页数：7
相关论文
共 57 条
[31]   REGULATION OF INTRACELLULAR BETA-CATENIN LEVELS BY THE ADENOMATOUS POLYPOSIS-COLI (APC) TUMOR-SUPPRESSOR PROTEIN [J].
MUNEMITSU, S ;
ALBERT, I ;
SOUZA, B ;
RUBINFELD, B ;
POLAKIS, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :3046-3050
[32]   DISHEVELLED AND ARMADILLO ACT IN THE WINGLESS SIGNALING PATHWAY IN DROSOPHILA [J].
NOORDERMEER, J ;
KLINGENSMITH, J ;
PERRIMON, N ;
NUSSE, R .
NATURE, 1994, 367 (6458) :80-83
[33]   A versatile transcriptional effector of wingless signaling [J].
Nusse, R .
CELL, 1997, 89 (03) :321-323
[34]   Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1 [J].
Okamura, RM ;
Sigvardsson, M ;
Galceran, J ;
Verbeek, S ;
Clevers, H ;
Grosschedl, R .
IMMUNITY, 1998, 8 (01) :11-20
[35]   An in vivo structure-function study of Armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling [J].
Orsulic, S ;
Peifer, M .
JOURNAL OF CELL BIOLOGY, 1996, 134 (05) :1283-1300
[36]  
Papkoff J, 1996, MOL CELL BIOL, V16, P2128
[37]  
PEIFER M, 1994, DEVELOPMENT, V120, P369
[38]   THE SEGMENT POLARITY GENE ARMADILLO ENCODES A FUNCTIONALLY MODULAR PROTEIN THAT IS THE DROSOPHILA HOMOLOG OF HUMAN PLAKOGLOBIN [J].
PEIFER, M ;
WIESCHAUS, E .
CELL, 1990, 63 (06) :1167-1178
[39]   Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin [J].
Porfiri, E ;
Rubinfeld, B ;
Albert, I ;
Hovanes, K ;
Waterman, M ;
Polakis, P .
ONCOGENE, 1997, 15 (23) :2833-2839
[40]   LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic [J].
Riese, J ;
Yu, XN ;
Munnerlyn, A ;
Eresh, S ;
Hsu, SC ;
Grosschedl, R ;
Bienz, M .
CELL, 1997, 88 (06) :777-787
123456