TCF: transcriptional activator or repressor?

被引：120
作者：
Bienz, M [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 03期
关键词：
D O I：
10.1016/S0955-0674(98)80013-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
T cell factor, or TCF, has been identified as the transcriptional response factor activated by Wnt-1 and Wingless signalling. TCF is thought to be a potent architectural factor which facilitates assembly of multiprotein enhancer complexes. Its deregulation in the colonic epithelium, and in other cells, leads to cancer. This raises the question of how TCF is kept inactive in unstimulated cells.
引用
收藏
页码：366 / 372
页数：7
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