TCF: transcriptional activator or repressor?

被引：120
作者：
Bienz, M [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 03期
关键词：
D O I：
10.1016/S0955-0674(98)80013-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
T cell factor, or TCF, has been identified as the transcriptional response factor activated by Wnt-1 and Wingless signalling. TCF is thought to be a potent architectural factor which facilitates assembly of multiprotein enhancer complexes. Its deregulation in the colonic epithelium, and in other cells, leads to cancer. This raises the question of how TCF is kept inactive in unstimulated cells.
引用
收藏
页码：366 / 372
页数：7
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共 57 条
[1]   An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro [J].
Bagga, R ;
Emerson, BM .
GENES & DEVELOPMENT, 1997, 11 (05) :629-639
[2]   Functional interaction of beta-catenin with the transcription factor LEF-1 [J].
Behrens, J ;
vonKries, JP ;
Kuhl, M ;
Bruhn, L ;
Wedlich, D ;
Grosschedl, R ;
Birchmeier, W .
NATURE, 1996, 382 (6592) :638-642
[3]   Endoderm induction in Drosophila: the nuclear targets of the inducing signals - Commentary [J].
Bienz, M .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (05) :683-688
[4]   A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus [J].
Brannon, M ;
Gomperts, M ;
Sumoy, L ;
Moon, RT ;
Kimelman, D .
GENES & DEVELOPMENT, 1997, 11 (18) :2359-2370
[5]   ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCR alpha enhancer function [J].
Bruhn, L ;
Munnerlyn, A ;
Grosschedl, R .
GENES & DEVELOPMENT, 1997, 11 (05) :640-653
[6]   pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila [J].
Brunner, E ;
Peter, O ;
Schweizer, L ;
Basler, K .
NATURE, 1997, 385 (6619) :829-833
[7]   Wnt signaling: a common theme in animal development [J].
Cadigan, KM ;
Nusse, R .
GENES & DEVELOPMENT, 1997, 11 (24) :3286-3305
[8]   THE HLEF/TCF-1-ALPHA HMG PROTEIN CONTAINS A CONTEXT-DEPENDENT TRANSCRIPTIONAL ACTIVATION DOMAIN THAT INDUCES THE TCR-ALPHA ENHANCER IN T-CELLS [J].
CARLSSON, P ;
WATERMAN, ML ;
JONES, KA .
GENES & DEVELOPMENT, 1993, 7 (12A) :2418-2430
[9]   Armadillo and dTCF: a marriage made in the nucleus [J].
Cavallo, R ;
Rubenstein, D ;
Peifer, M .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (04) :459-466
[10]   TCF/LEF factors earn their wings [J].
Clevers, H ;
Van de Wetering, M .
TRENDS IN GENETICS, 1997, 13 (12) :485-489
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