Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers

被引：8

作者：

Xiao, Guodong ^{[1
]}

Meng, Jinying ^{[2
]}

Zhang, Jing ^{[1
]}

Li, Gang ^{[1
]}

Du, Ning ^{[1
]}

Qin, Sida ^{[1
]}

Wang, Jichang ^{[3
]}

Xu, Chongwen ^{[4
]}

Ren, Hong ^{[1
]}

Tang, Shou-Ching ^{[5
,6
]}

Sun, Xin ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Thorac Surg 2, Dept Thorac Surg & Oncol,Canc Ctr, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China

[2] First Peoples Hosp Xianyang City, Dept Surg Oncol, Xianyang, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Vasc & Endovasc Surg, Xian, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Xian, Shaanxi, Peoples R China

[5] Augusta Univ, Med Coll Georgia, Georgia Canc Ctr, Solid Tumor Clin Trials, 1411 Laney Walker Blvd, Augusta, GA 30912 USA

[6] Tianjin Med Univ Canc Inst & Hosp, Tianjin, Peoples R China

来源：

CANCER INVESTIGATION | 2017年 / 35卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Breast cancer; 21-Gene recurrence score; Cancer stem cells; Recurrence risk; ONCOTYPE DX; TREATMENT RECOMMENDATIONS; DECISION-MAKING; ASSAY; CHEMOTHERAPY; POPULATION; EXPRESSION; IMPACT; CELLS;

D O I：

10.1080/07357907.2017.1405015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (>= 31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.

引用

收藏

页码：639 / 646

页数：8

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