Phylogeographic Evidence for 2 Genetically Distinct Zoonotic Plasmodium knowlesi Parasites, Malaysia

被引：47

作者：

Yusof, Ruhani ^{[1
]}

Ahmed, Md Atique ^{[1
]}

Jelip, Jenarun ^{[2
]}

Ngian, Hie Ung ^{[3
]}

Mustakim, Sahlawati ^{[4
]}

Hussin, Hani Mat ^{[5
]}

Fong, Mun Yik ^{[1
]}

Mahmud, Rohela ^{[1
]}

Sitam, Frankie Anak Thomas ^{[6
]}

Japning, J. Rovie-Ryan ^{[6
]}

Snounou, Georges ^{[7
,8
]}

Escalante, Ananias A. ^{[8
]}

Lau, Yee Ling ^{[1
]}

机构：

[1] Univ Malaya, Fac Med, Kuala Lumpur, Malaysia

[2] Sabah State Hlth Dept, Sabah, Malaysia

[3] Hosp Kapit, Sarawak, Malaysia

[4] Hosp Tengku, Microbiol Lab, Ampuan Rahimah, Selangor, Malaysia

[5] Kelantan State Hlth Dept, Kelantan, Malaysia

[6] Dept Wildlife & Natl Pk Peninsular Malaysia, Kuala Lumpur, Malaysia

[7] Sorbonne Univ, INSERM, Paris, France

[8] Temple Univ, Philadelphia, PA 19122 USA

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 08期

关键词：

STATISTICAL TESTS; MALARIA; INFECTIONS; NEUTRALITY; CLUSTERS; SOFTWARE; ORIGIN;

D O I：

10.3201/eid2208.151885

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infections of humans with the zoonotic simian malaria parasite Plasmodium knowlesi occur throughout Southeast Asia, although most cases have occurred in Malaysia, where P. knowlesi is now the dominant malaria species. This apparently skewed distribution prompted an investigation of the phylogeography of this parasite in 2 geographically separated regions of Malaysia, Peninsular Malaysia and Malaysian Borneo. We investigated samples collected from humans and macaques in these regions. Haplotype network analyses of sequences from 2 P. knowlesi genes, type A small subunit ribosomal 18S RNA and cytochrome c oxidase subunit I, showed 2 genetically distinct divergent clusters, 1 from each of the 2 regions of Malaysia. We propose that these parasites represent 2 distinct P. knowlesi types that independently became zoonotic. These types would have evolved after the sea-level rise at the end of the last ice age, which separated Malaysian Borneo from Peninsular Malaysia.

引用

页码：1371 / 1380

页数：10

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