Readily available catalysts for demanding Suzuki-Miyaura couplings under mild conditions

被引：26

作者：

Demchuk, Oleg M. ^{[1
]}

Kaplon, Katarzyna ^{[1
]}

Mazur, Liliana ^{[1
]}

Strzelecka, Dorota ^{[1
]}

Pietrusiewicz, K. Michal ^{[1
]}

机构：

[1] Marie Curie Sklodowska Univ, Dept Organ Chem, 33 Gliniana St, PL-20614 Lublin, Poland

来源：

TETRAHEDRON | 2016年 / 72卷 / 42期

关键词：

Cross-coupling; C; P-complexation; Aqueous media; Suzuld-Miyaura coupling; Heck reaction; Catalyst structure; BIARYL NATURAL-PRODUCTS; RATIONAL LIGAND DESIGN; 2-AMINO-2'-DIPHENYLPHOSPHINO-1,1'-BINAPHTHYL MAP; CROSS-COUPLINGS; CHEMISTRY; GREEN; WATER; HECK; PHOSPHINES; COMPLEXES;

D O I：

10.1016/j.tet.2016.08.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward synthesis of a sterically hindered and electron rich bidentate monophosphine biaryl ligand Sym-Phos of C,P-type of complexation was realised in a high yield starting from simple substrates in easily affordable conditions. In combination with a palladium source, the obtained ligand formed a highly active catalyst mediating sterically demanding Suzuki-Miyaura coupling reactions in aqueous media even at 60 degrees C and with no need to protect the reaction mixture by an inert gas. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：6668 / 6677

页数：10

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