Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma

被引：107

作者：

Tam, Samantha ^{[1
]}

Amit, Moran ^{[1
]}

Zafereo, Mark ^{[1
]}

Bell, Diana ^{[2
]}

Weber, Randal S. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Div Surg, Dept Head & Neck Surg, 1515 Holcombe Blvd,Suite 1445, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Div Pathol Lab Med, Houston, TX 77030 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 01期

关键词：

lymph node excision; mouth neoplasms; prognosis; squamous cell carcinoma; tongue neoplasms; PROGNOSTIC-FACTORS; TUMOR THICKNESS; NECK DISSECTION; STAGE-I; MOBILE TONGUE; RISK-FACTORS; METASTASIS; CAVITY; FLOOR; MULTICENTER;

D O I：

10.1002/hed.25506

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival. Methods A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. DOI cut-points were computed. Multiple logistic regression and multivariate Cox proportional hazards models were used to assess predictors of occult nodal disease and overall survival (OS) and disease-specific survival (DSS). Results Occult nodal disease was found in 55 (26%) of the 212 patients. DOI of 7.25 mm was most predictive for occult nodal disease and 8 mm for OS and DSS. DOI was an independent predictor of OS and DSS. Conclusion The optimal DOI cut-point for detection of occult nodal metastasis was 7.25 and 8 mm for OS and DSS at 5 years. DOI is an independent predictor of OS and DSS.

引用

页码：177 / 184

页数：8

共 40 条

[1] Early stage carcinoma of oral tongue: prognostic factors for local control and survival [J].

Al-Rajhi, N ;

Khafaga, Y ;

El-Husseiny, J ;

Saleem, M ;

Mourad, W ;

Al-Otieschan, A ;

Al-Amro, A .

ORAL ONCOLOGY, 2000, 36 (06) :508-514

[2]

Amin MB., 2017, AJCC cancer staging manual, V8th

[3] Development of a New Outcome Prediction Model in Early-stage Squamous Cell Carcinoma of the Oral Cavity Based on Histopathologic Parameters With Multivariate Analysis: The Aditi-Nuzhat Lymph-node Prediction Score (ANLPS) System [J].

Arora, Aditi ;

Husain, Nuzhat ;

Bansal, Ankur ;

Neyaz, Azfar ;

Jaiswal, Ritika ;

Jain, Kavitha ;

Chaturvedi, Arun ;

Anand, Nidhi ;

Malhotra, Kiranpreet ;

Shukla, Saumya .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017, 41 (07) :950-960

[4]

BROWN B, 1989, CANCER-AM CANCER SOC, V64, P1195, DOI 10.1002/1097-0142(19890915)64:6<1195::AID-CNCR2820640606>3.0.CO

[5]

2-7

[6]

Byers RM, 1998, HEAD NECK-J SCI SPEC, V20, P138, DOI 10.1002/(SICI)1097-0347(199803)20:2<138::AID-HED7>3.0.CO

[7]

2-3

[8] Sentinel Lymph Node Biopsy Accurately Stages the Regional Lymph Nodes for T1-T2 Oral Squamous Cell Carcinomas: Results of a Prospective Multi-Institutional Trial [J].

Civantos, Francisco J. ;

Zitsch, Robert P. ;

Schuller, David E. ;

Agrawal, Amit ;

Smith, Russell B. ;

Nason, Richard ;

Petruzelli, Guy ;

Gourin, Christine G. ;

Wong, Richard J. ;

Ferris, Robert L. ;

El Naggar, Adel ;

Ridge, John A. ;

Paniello, Randal C. ;

Owzar, Kouros ;

McCall, Linda ;

Chepeha, Douglas B. ;

Yarbrough, Wendell G. ;

Myers, Jeffrey N. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (08) :1395-1400

[9] Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer [J].

D'Cruz, Anil K. ;

Vaish, Richa ;

Kapre, Neeti ;

Dandekar, Mitali ;

Gupta, Sudeep ;

Hawaldar, Rohini ;

Agarwal, Jai Prakash ;

Pantvaidya, Gouri ;

Chaukar, Devendra ;

Deshmukh, Anuja ;

Kane, Shubhada ;

Arya, Supreeta ;

Ghosh-Laskar, Sarbani ;

Chaturvedi, Pankaj ;

Pai, Prathamesh ;

Nair, Sudhir ;

Nair, Deepa ;

Badwe, Rajendra .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (06) :521-529

[10] Primary Tumor Staging for Oral Cancer and a Proposed Modification Incorporating Depth of Invasion An International Multicenter Retrospective Study [J].

Ebrahimi, Ardalan ;

Gil, Ziv ;

Amit, Moran ;

Yen, Tzu-Chen ;

Liao, Chun-Ta ;

Chaturvedi, Pankaj ;

Agarwal, Jai Prakash ;

Kowalski, Luiz P. ;

Kreppel, Matthias ;

Cernea, Claudio R. ;

Brandao, Jose ;

Bachar, Gideon ;

Villaret, Andrea Bolzoni ;

Fliss, Dan ;

Fridman, Eran ;

Robbins, K. Thomas ;

Shah, Jatin P. ;

Patel, Snehal G. ;

Clark, Jonathan R. .

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2014, 140 (12) :1138-1148

← 1 2 3 4 →