Revisiting the embryogenesis of lip and palate development

被引：54

作者：

Hammond, Nigel L. ^{[1
]}

Dixon, Michael J. ^{[1
]}

机构：

[1] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England

来源：

ORAL DISEASES | 2022年 / 28卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

cleft lip; cleft palate; facial development; PROGRAMMED CELL-DEATH; EDGE EPITHELIAL-CELLS; GENOME-WIDE METAANALYSES; NONSYNDROMIC CLEFT-LIP; SECONDARY PALATE; EXPRESSION PATTERNS; SONIC HEDGEHOG; TRANSCRIPTION FACTOR; SIGNALING PATHWAY; MOUSE DEVELOPMENT;

D O I：

10.1111/odi.14174

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Clefts of the lip and palate (CLP), the major causes of congenital facial malformation globally, result from failure of fusion of the facial processes during embryogenesis. With a prevalence of 1 in 500-2500 live births, CLP causes major morbidity throughout life as a result of problems with facial appearance, feeding, speaking, obstructive apnoea, hearing and social adjustment and requires complex, multi-disciplinary care at considerable cost to healthcare systems worldwide. Long-term outcomes for affected individuals include increased mortality compared with their unaffected siblings. The frequent occurrence and major healthcare burden imposed by CLP highlight the importance of dissecting the molecular mechanisms driving facial development. Identification of the genetic mutations underlying syndromic forms of CLP, where CLP occurs in association with non-cleft clinical features, allied to developmental studies using appropriate animal models is central to our understanding of the molecular events underlying development of the lip and palate and, ultimately, how these are disturbed in CLP.

引用

页码：1306 / 1326

页数：21

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