Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats

被引:13
作者
Ezzeldin, Essam [1 ,2 ]
Asiri, Yousif A. [3 ]
Iqbal, Muzaffar [1 ,2 ]
机构
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Bioavailabil Lab, Riyadh 11451, Saudi Arabia
[3] King Saud Univ, Coll Pharm, Dept Clin Pharm, Riyadh 11451, Saudi Arabia
关键词
EPIGALLOCATECHIN GALLATE; BIPOLAR DEPRESSION; DRUG-INTERACTION; P-GLYCOPROTEIN; METABOLITE; CANCER; (-)-EPIGALLOCATECHIN-3-GALLATE; BIOAVAILABILITY; POLYPHENOLS; MECHANISMS;
D O I
10.1155/2015/615285
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Quetiapine is an atypical antipsychotic, used clinically in the treatment of schizophrenia, acute mania in bipolar disorders, and bipolar depression in adults. In this study, the effect of green tea extracts (GTE) on the pharmacokinetics of quetiapine (substrate of CYP3A4) was investigated in rats. Male Wistar albino rats received GTE (175 mg/kg) or saline (control) by oral gavage for 7 days before a single intragastric administration of 25 mg/kg quetiapine. Plasma concentrations of quetiapine were measured up to 12 h after its administration by a validated ultraperformance liquid chromatography-tandem mass spectroscopy. Pretreatment with GTE produced significant reductions in the maximum plasma concentration and area under the curve of quetiapine by 45% and 35%, respectively, compared to quetiapine alone. However, GTE did not produce significant change in elimination half-life and oral clearance of quetiapine. This study concluded that GTE may decrease the bioavailability of quetiapine when coadministered.
引用
收藏
页数:4
相关论文
共 50 条
[41]   Metabolism of green tea catechins by the human small intestine [J].
Schantz, Markus ;
Erk, Thomas ;
Richling, Elke .
BIOTECHNOLOGY JOURNAL, 2010, 5 (10) :1050-1059
[42]   Beverage-Drug Interaction: Effects of Green Tea Beverage Consumption on Atorvastatin Metabolism and Membrane Transporters in the Small Intestine and Liver of Rats [J].
Yao, Hsien-Tsung ;
Hsu, Ya-Ru ;
Li, Mei-Ling .
MEMBRANES, 2020, 10 (09) :1-12
[43]   Beneficial effects of cocoa, coffee, green tea, and garcinia complex supplement on diet induced obesity in rats [J].
Huang, Chi-Chang ;
Tung, Yu-Tang ;
Huang, Wen-Ching ;
Chen, Yi-Ming ;
Hsu, Yi-Ju ;
Hsu, Mei-Chich .
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 16
[44]   Effects of verapamil on the pharmacokinetics of puerarin in rats [J].
Zhou, Yun ;
Song, Xiaoli ;
Dong, Gang .
XENOBIOTICA, 2019, 49 (10) :1178-1182
[45]   Effects of quercetin on the pharmacokinetics of erlotinib in rats [J].
Shen, Xiuwei ;
Chen, Fan ;
Wang, Fengwei ;
Liu, Jipiao ;
Huang, Peng .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (12) :13627-13632
[46]   Effects of Cysteine on the Pharmacokinetics of Paclitaxel in Rats [J].
Lee, Yu Kyung ;
Han, Seung Yon ;
Chin, Young-Won ;
Choi, Young Hee .
ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (03) :509-516
[47]   The Effects of Verapamil on the Pharmacokinetics of Paeoniflorin in Rats [J].
Liu, Lu ;
Li, Xiaohua ;
Yuan, Yawei ;
Li, Pihong .
LATIN AMERICAN JOURNAL OF PHARMACY, 2019, 38 (02) :329-334
[48]   Effects of liquorice on pharmacokinetics of aconitine in rats [J].
He, Yufei ;
Wei, Zihong ;
Ci, Xiaoyan ;
Xie, Ying ;
Yi, Xiulin ;
Zeng, Yong ;
Li, Yazhuo ;
Liu, Changxiao .
XENOBIOTICA, 2019, 49 (12) :1485-1493
[49]   GENOTOXIC EFFECTS OF GREEN TEA EXTRACT ON HUMAN LARYNGEAL CARCINOMA CELLS IN VITRO [J].
Durgo, Ksenija ;
Kostic, Sandra ;
Gradiski, Katarina ;
Komes, Drazenka ;
Osmak, Maja ;
Franekic, Jasna .
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, 2011, 62 (02) :139-146
[50]   Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice [J].
Zhu, Chuang ;
Tai, Ling-Ling ;
Wan, Xiao-chun ;
Li, Da-xiang ;
Zhao, Yong-Qing ;
Xu, Yan .
PHARMACEUTICAL BIOLOGY, 2017, 55 (01) :2123-2128