Diagnostic accuracy of cardiopulmonary ultrasound for pulmonary embolism: A systematic review and meta-analysis

Background Cardiopulmonary ultrasound has shown varying results in the diagnosis of pulmonary embolism patients around the world. Hence, the current review was done to assess the diagnostic accuracy of cardiopulmonary ultrasound for diagnosis of pulmonary embolism among suspected patients. Methods We conducted a systematic search for all studies reporting the diagnostic accuracy of cardiopulmonary ultrasound for pulmonary embolism in the databases of MEDLINE, EMBASE, MEDLINE, SCOPUS, and Cochrane library from inception till May 2021. Meta-analysis was performed using STATA software "midas" package. Results Ten studies with 4216 patients were included. The pooled sensitivity was 77% (95% CI, 50-92%) and specificity was 99% (95% CI, 97-100%), respectively. The pooled DOR was 382 (95% CI, 77-1883). Pooled LRP was 90 (95% CI, 24-326) and pooled LRN was .23 (.09-.58). There was significant heterogeneity found with the outcome with significant chi-square test and I2 statistic > 75%. Conclusion Cardiopulmonary ultrasound has the ability to be used as an adjunct to CTPA especially in resource constrained settings. Further reviews comparing multiple non-invasive imaging modalities are required to pick the best tool for diagnosis of pulmonary embolism.