Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project

被引：19

作者：

Verhaar, Barbara J. H. ^{[1
,2
]}

de Leeuw, Francisca A. ^{[1
,3
]}

Doorduijn, Astrid S. ^{[1
,4
]}

Fieldhouse, Jay L. P. ^{[1
]}

van de Rest, Ondine ^{[5
]}

Teunissen, Charlotte E. ^{[3
]}

van Berckel, Bart N. M. ^{[6
]}

Barkhof, Frederik ^{[1
,6
,7
]}

Visser, Marjolein ^{[8
]}

de van der Schueren, Marian A. E. ^{[4
,9
]}

Scheltens, Philip ^{[1
]}

Kester, Maartje, I ^{[1
]}

Muller, Majon ^{[2
]}

van der Flier, Wiesje M. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Amsterdam Cardiovasc Sci, Dept Internal Med, Amsterdam UMC, POB 7057, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Amsterdam Neurosci, Dept Clin Chem, Amsterdam UMC, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Nutr & Dietet, Amsterdam UMC, Amsterdam, Netherlands

[5] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands

[6] Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[7] UCL Inst Neurol & Healthcare Engn, London, England

[8] Vrije Univ Amsterdam, Fac Sci, Dept Hlth Sci, Amsterdam, Netherlands

[9] HAN Univ Appl Sci, Dept Nutr & Hlth, Nijmegen, Netherlands

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2020年 / 12卷 / 01期

关键词：

body mass index; cerebral atrophy; fat free mass; fat mass; malnutrition; microbleeds; mild cognitive impairment; magnetic resonance imaging; nutritional status; white matter hyperintensities; WHITE-MATTER HYPERINTENSITIES; MINI-MENTAL-STATE; BODY-MASS INDEX; WEIGHT-LOSS; DEMENTIA; DIAGNOSIS; ATROPHY; RISK; MRI; ASSOCIATION;

D O I：

10.1002/dad2.12063

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionWeight loss is associated with higher mortality and progression of cognitive decline, but its associations with magnetic resonance imaging (MRI) changes related to Alzheimer's disease (AD) are unknown. MethodsWe included 412 patients from the NUDAD project, comprising 129 with AD dementia, 107 with mild cognitive impairment (MCI), and 176 controls. Associations between nutritional status and MRI measures were analyzed using linear regression, adjusted for age, sex, education, cognitive functioning, and cardiovascular risk factors. ResultsLower body mass index (BMI), fat mass (FM), and fat free mass index were associated with higher medial temporal atrophy (MTA) scores. Lower BMI, FM, and waist circumference were associated with more microbleeds. Stratification by diagnosis showed that the observed associations with microbleeds were only significant in MCI. DiscussionLower indicators of nutritional status were associated with more MTA and microbleeds, with largest effect sizes in MCI.

引用

页数：9

共 41 条

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