Granisetron potentiometric sensor based on computational study

被引：0
作者：
Ganjali, Mohammad Reza [1 ,2 ]
Aboufazeli, Forouzan [1 ]
Faridbod, Farnoush [2 ]
Riahi, Siavash [1 ,3 ]
Norouzi, Parviz [1 ,2 ]
机构：
[1] Univ Tehran, Fac Chem, Ctr Excellence Electrochem, Tehran, Iran
[2] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Tehran, Iran
[3] Univ Tehran, Fac Engn, Inst Petr Engn, Tehran, Iran
来源：
CHIMICA OGGI-CHEMISTRY TODAY | 2010年 / 28卷 / 05期
关键词：
Potentiometric sensor; PVC membrane; Granisetron hydrochloride; Computational Chemistry; Chemometrics; Density functional based tight binding (DFTB); CONTINUOUS CYCLIC VOLTAMMETRY; NANO-LEVEL DETECTION; AU MICROELECTRODE; MEMBRANE SENSOR; HYDROCHLORIDE; FORMULATION;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Granisetron (GRN) prevent the nausea and vomiting that may occur after treatment with anticancer medicines in chemotherapy or radiation therapy. In this study, a potentiometric liquid membrane sensor for simple and fast quantification of granisetron hydrochloride in pharmaceutical formulation and urine was made. Based on some theoretical calculations, GRN-tetraphenylborate ion pair was selected as a sensing material in the organic phase of the PVC membrane. The wide linear range (10-5-10-2 mol L-1), low detection limit (7.8x10-6 mol L-1), and fast response time (similar to 35 s) are the characterizations of this electrochemical sensor. Validation of the method confirms suitability of the sensor for use in the quality control analysis of granisetron hydrochloride in pharmaceutical formulation.
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收藏
页码：4 / 9
页数：6
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