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Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling
被引:33
作者:

Gu, Linlin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

Surolia, Ranu
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

Larson-Casey, Jennifer L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

He, Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

Davis, Dana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

Kang, Jungsoon
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

Antony, Veena B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

Carter, A. Brent
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA
Birmingham VAMC, Birmingham, AL 35233 USA Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA
机构:
[1] Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA
[2] Birmingham VAMC, Birmingham, AL 35233 USA
关键词:
MITOCHONDRIAL CALCIUM UNIPORTER;
ENDOPLASMIC-RETICULUM STRESS;
FATTY-ACID OXIDATION;
PULMONARY-FIBROSIS;
BH4;
DOMAIN;
ALTERNATIVE ACTIVATION;
CELL APOPTOSIS;
BCL-2;
INHIBITION;
MACROPHAGES;
D O I:
10.1038/s41418-021-00840-w
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The mitochondrial calcium uniporter (MCU) regulates metabolic reprogramming in lung macrophages and the progression of pulmonary fibrosis. Fibrosis progression is associated with apoptosis resistance in lung macrophages; however, the mechanism(s) by which apoptosis resistance occurs is poorly understood. Here, we found a marked increase in mitochondrial B-cell lymphoma-2 (Bcl-2) in lung macrophages from subjects with idiopathic pulmonary fibrosis (IPF). Similar findings were seen in bleomycin-injured wild-type (WT) mice, whereas Bcl-2 was markedly decreased in mice expressing a dominant-negative mitochondrial calcium uniporter (DN-MCU). Carnitine palmitoyltransferase 1a (Cpt1a), the rate-limiting enzyme for fatty acid beta-oxidation, directly interacted with Bcl-2 by binding to its BH3 domain, which anchored Bcl-2 in the mitochondria to attenuate apoptosis. This interaction was dependent on Cpt1a activity. Lung macrophages from IPF subjects had a direct correlation between CPT1A and Bcl-2, whereas the absence of binding induced apoptosis. The deletion of Bcl-2 in macrophages protected mice from developing pulmonary fibrosis. Moreover, mice had resolution when Bcl-2 was deleted or was inhibited with ABT-199 after fibrosis was established. These observations implicate an interplay between macrophage fatty acid beta-oxidation, apoptosis resistance, and dysregulated fibrotic remodeling.
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页码:118 / 132
页数:15
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[1]
Proapoptotic bid is required for pulmonary fibrosis
[J].
Budinger, GRS
;
Mutlu, GM
;
Eisenbart, J
;
Fuller, AC
;
Bellmeyer, AA
;
Baker, CM
;
Wilson, M
;
Ridge, K
;
Barrett, TA
;
Lee, VY
;
Chandel, NS
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2006, 103 (12)
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Northwestern Univ, Dept Med, Chicago, IL 60611 USA Northwestern Univ, Dept Med, Chicago, IL 60611 USA
[2]
Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
[J].
Camarda, Roman
;
Zhou, Alicia Y.
;
Kohnz, Rebecca A.
;
Balakrishnan, Sanjeev
;
Mahieu, Celine
;
Anderton, Brittany
;
Eyob, Henok
;
Kajimura, Shingo
;
Tward, Aaron
;
Krings, Gregor
;
Nomura, Daniel K.
;
Goga, Andrei
.
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Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA
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[3]
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria (vol 14, pg 2313, 2016)
[J].
Cardenas, Cesar
;
Mueller, Marioly
;
McNeal, Andrew
;
Lovy, Alenka
;
Jana, Fabian
;
Bustos, Galdo
;
Urra, Felix
;
Smith, Natalia
;
Molgo, Jordi
;
Diehl, J. Alan
;
Ridky, Todd W.
;
Foskett, J. Kevin
.
CELL REPORTS,
2016, 15 (01)
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Cardenas, Cesar
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Mueller, Marioly
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McNeal, Andrew
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Lovy, Alenka
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Bustos, Galdo
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Urra, Felix
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h-index: 0

Smith, Natalia
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h-index: 0

Molgo, Jordi
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Ridky, Todd W.
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Foskett, J. Kevin
论文数: 0 引用数: 0
h-index: 0
[4]
Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer
[J].
Catz, SD
;
Johnson, JL
.
ONCOGENE,
2001, 20 (50)
:7342-7351

Catz, SD
论文数: 0 引用数: 0
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Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

Johnson, JL
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Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[5]
PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis
[J].
Chipuk, Jerry E.
;
Green, Douglas R.
.
CELL CYCLE,
2009, 8 (17)
:2692-2696

Chipuk, Jerry E.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

Green, Douglas R.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA
[6]
Bcl-xL promotes metastasis independent of its anti-apoptotic activity
[J].
Choi, Soyoung
;
Chen, Zhengming
;
Tang, Laura H.
;
Fang, Yuanzhang
;
Shin, Sandra J.
;
Panarelli, Nicole C.
;
Chen, Yao-Tseng
;
Li, Yi
;
Jiang, Xuejun
;
Du, Yi-Chieh Nancy
.
NATURE COMMUNICATIONS,
2016, 7

Choi, Soyoung
论文数: 0 引用数: 0
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Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Chen, Zhengming
论文数: 0 引用数: 0
h-index: 0
机构:
Weill Cornell Med, Div Biostat & Epidemiol, Dept Healthcare Policy & Res, New York, NY 10065 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Tang, Laura H.
论文数: 0 引用数: 0
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Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Fang, Yuanzhang
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Shin, Sandra J.
论文数: 0 引用数: 0
h-index: 0
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Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Panarelli, Nicole C.
论文数: 0 引用数: 0
h-index: 0
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Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Chen, Yao-Tseng
论文数: 0 引用数: 0
h-index: 0
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Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Li, Yi
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Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Jiang, Xuejun
论文数: 0 引用数: 0
h-index: 0
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Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

Du, Yi-Chieh Nancy
论文数: 0 引用数: 0
h-index: 0
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Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA
[7]
Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
[J].
Czabotar, Peter E.
;
Westphal, Dana
;
Dewson, Grant
;
Ma, Stephen
;
Hockings, Colin
;
Fairlie, W. Douglas
;
Lee, Erinna F.
;
Yao, Shenggen
;
Robin, Adeline Y.
;
Smith, Brian J.
;
Huang, David C. S.
;
Kluck, Ruth M.
;
Adams, Jerry M.
;
Colman, Peter M.
.
CELL,
2013, 152 (03)
:519-531

Czabotar, Peter E.
论文数: 0 引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
Univ Melbourne, Dept Med Biol, Melbourne, Vic 3052, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia

Westphal, Dana
论文数: 0 引用数: 0
h-index: 0
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Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
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Dewson, Grant
论文数: 0 引用数: 0
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h-index:
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Hockings, Colin
论文数: 0 引用数: 0
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Fairlie, W. Douglas
论文数: 0 引用数: 0
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Lee, Erinna F.
论文数: 0 引用数: 0
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Yao, Shenggen
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Robin, Adeline Y.
论文数: 0 引用数: 0
h-index: 0
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Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
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Smith, Brian J.
论文数: 0 引用数: 0
h-index: 0
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La Trobe Univ, La Trobe Inst Mol Sci, Bundoora, Vic 3086, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia

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Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
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Kluck, Ruth M.
论文数: 0 引用数: 0
h-index: 0
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Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
Univ Melbourne, Dept Med Biol, Melbourne, Vic 3052, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia

Adams, Jerry M.
论文数: 0 引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
Univ Melbourne, Dept Med Biol, Melbourne, Vic 3052, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia

Colman, Peter M.
论文数: 0 引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
Univ Melbourne, Dept Med Biol, Melbourne, Vic 3052, Australia Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
[8]
Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis
[J].
Dai, Haiming
;
Meng, X. Wei
;
Lee, Sun-Hee
;
Schneider, Paula A.
;
Kaufmann, Scott H.
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2009, 284 (27)
:18311-18322

Dai, Haiming
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA

Meng, X. Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA
Mayo Clin, Dept Mol Pharmacol, Rochester, MN 55905 USA Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA

Lee, Sun-Hee
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Mol Pharmacol, Rochester, MN 55905 USA Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA

Schneider, Paula A.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA

Kaufmann, Scott H.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA
Mayo Clin, Dept Mol Pharmacol, Rochester, MN 55905 USA Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA
[9]
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation
[J].
Diwan, Abhinav
;
Wansapura, Janaka
;
Syed, Faisal M.
;
Matkovich, Scot J.
;
Lorenz, John N.
;
Dorn, Gerald W., II
.
CIRCULATION,
2008, 117 (03)
:396-404

Diwan, Abhinav
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA

Wansapura, Janaka
论文数: 0 引用数: 0
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Childrens Hosp, Med Ctr, Dept Radiol, Imaging Res Ctr, Cincinnati, OH 45229 USA Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA

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论文数: 0 引用数: 0
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Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA

Matkovich, Scot J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA

Lorenz, John N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Dept Mol & Cellular Physiol, Cincinnati, OH 45267 USA Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA

Dorn, Gerald W., II
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA
Univ Cincinnati, Dept Pediat, Cincinnati, OH 45267 USA Univ Cincinnati, Ctr Mol Cardiovasc Res, Cincinnati, OH 45267 USA
[10]
Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction
[J].
Docherty, NG
;
O'Sullivan, OE
;
Healy, DA
;
Fitzpatrick, JM
;
Watson, RWG
.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY,
2006, 290 (01)
:F4-F13

Docherty, NG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Coll Dublin, Conway Inst Biomol & Biomed Sci, Dept Surg, Dublin 4, Ireland

O'Sullivan, OE
论文数: 0 引用数: 0
h-index: 0
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Healy, DA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Coll Dublin, Conway Inst Biomol & Biomed Sci, Dept Surg, Dublin 4, Ireland

Fitzpatrick, JM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Coll Dublin, Conway Inst Biomol & Biomed Sci, Dept Surg, Dublin 4, Ireland

Watson, RWG
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coll Dublin, Conway Inst Biomol & Biomed Sci, Dept Surg, Dublin 4, Ireland Univ Coll Dublin, Conway Inst Biomol & Biomed Sci, Dept Surg, Dublin 4, Ireland