Neuroendocrine regulation of GnRH release and expression of GnRH and GnRH receptor genes in the hypothalamus-pituitary unit in different physiological states

被引：52
作者：
Ciechanowska, Magdalena [1 ]
Lapot, Magdalena [1 ]
Mateusiak, Krystyna [1 ]
Przekop, Franciszek [1 ]
机构：
[1] Polish Acad Sci, Kielanowski Inst Anim Physiol & Nutr, PL-05110 Jablonna, Poland
来源：
REPRODUCTIVE BIOLOGY | 2010年 / 10卷 / 02期
关键词：
ewe; hypothalamus; GnRH mRNA; GnRHR mRNA; LH; LUTEINIZING-HORMONE SECRETION; GAMMA-AMINOBUTYRIC-ACID; MESSENGER-RIBONUCLEIC-ACID; MEDIAL PREOPTIC AREA; PULSATILE LH-SECRETION; SIGNAL-TRANSDUCTION PATHWAYS; ARCUATE-VENTROMEDIAL REGION; II GLUCOCORTICOID-RECEPTOR; STRESS-INDUCED SUPPRESSION; FOLLICULAR PHASE EWES;
D O I：
10.1016/S1642-431X(12)60054-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This review is focused on the relationship between neuroendocrine regulation of GnRH/LH secretion and the expression of GnRH and GnRH receptor (GnRHR) genes in the hypothalamic-pituitary unit during different physiological states of animals and under stress. Moreover, the involvement of hypothalamic GABA-ergic, beta-endorphinergic, CRH-ergic, noradrenergic, dopaminergic and GnRH-ergic systems in the regulation of expression of the GnRH and GnRHR genes as well as secretion of GnRH/LH is analyzed. It appears that the neural mechanisms controlling GnRH gene expression in different physiological states may be distinct from those regulating GnRH/LH release. The hypothalamic GnRHR gene is probably located in different neural systems and may act in a specific way on GnRH gene expression and GnRH release. Reproductive Biology 2010 10 2: 85-124.
引用
收藏
页码：85 / 124
页数：40
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